You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POU3F3
POU domain, class 3, transcription factor 3

Protein Summary
Description
Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361360
  • ENSP00000355001
  • ENSG00000198914

Symbol
  • BRN1
  • OTF8
  • BRN1
  • OTF8
  • oct-8
  • brain-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.85
gene perturbation
0.81
phenotype
0.65
PubMedID
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.12   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.12   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
MYT1L
Tbio
Family:  TF
Novelty:  0.0174369
Score:  0.776
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.755
Data Source:  STRINGDB
TBR1
Tbio
Family:  TF
Novelty:  0.00676736
Score:  0.737
Data Source:  STRINGDB
SOX11
Tbio
Family:  TF
Novelty:  0.00516158
Score:  0.717
Data Source:  STRINGDB
NPAS3
Tbio
Family:  TF
Novelty:  0.02597048
Score:  0.707
Data Source:  STRINGDB
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.692
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.687
Data Source:  STRINGDB
NPAS1
Tbio
Family:  TF
Novelty:  0.08014425
Score:  0.67
Data Source:  STRINGDB
DLL1
Tbio
Novelty:  0.00150384
Score:  0.66
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.619
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
4
5
87.5
brain measurement
1
1
0
13.9
73.7
cortical surface area measurement
1
1
0
10.8
68.8
body height
1
1
1
58.5
lifestyle measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
87.5
brain measurement
0
13.9
73.7
cortical surface area measurement
0
10.8
68.8
body height
1
58.5
lifestyle measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102564
18993
Rat
RGD:619768
192109
Xenopus
POU class 3 homeobox 3
XB-GENE-920672
100497507
Zebrafish
ZDB-GENE-980526-140
30321
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Xenopus
POU class 3 homeobox 3
Zebrafish
Publication Statistics
PubMed Score 143.12
PubMed score by year
PubTator Score 99.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title