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Tbio
POU3F2
POU domain, class 3, transcription factor 2

Protein Summary
Description
Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328345
  • ENSP00000329170
  • ENSG00000184486

Symbol
  • BRN2
  • OCT7
  • OTF7
  • BRN2
  • OCT7
  • OTF7
  • OTF-7
  • POUF3
  • brn-2
  • oct-7
  • N-Oct3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.85
molecular function
0.67
transcription factor binding site profile
0.66
gene perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.24   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.24   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.895
Data Source:  STRINGDB
MYT1L
Tbio
Family:  TF
Novelty:  0.0174369
Score:  0.863
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.836
Data Source:  STRINGDB
ARNT2
Tbio
Family:  TF
Novelty:  0.01485424
Score:  0.824
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.804
Data Source:  STRINGDB
MITF
Tchem
Family:  TF
Novelty:  0.00094044
Score:  0.779
Data Source:  STRINGDB
SOX11
Tbio
Family:  TF
Novelty:  0.00516158
Score:  0.759
Data Source:  STRINGDB
NES
Tbio
Novelty:  0.00035379
Score:  0.738
Data Source:  STRINGDB
NPAS3
Tbio
Family:  TF
Novelty:  0.02597048
Score:  0.733
Data Source:  STRINGDB
SOX1
Tbio
Family:  TF
Novelty:  0.0045679
Score:  0.72
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
miRs in Muscle Cell Differentiation
Name
Explore in Pharos
Explore in Source
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
MECP2 and Associated Rett Syndrome
miRs in Muscle Cell Differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
2
3
57.7
mathematical ability
3
1
3
56.6
intelligence
1
2
0
6
46.4
self reported educational attainment
2
2
2
28.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
57.7
mathematical ability
3
56.6
intelligence
0
6
46.4
self reported educational attainment
2
28.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:101895
18992
Rat
RGD:61946
29588
Pig
POU class 3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9215]
Opossum
POU class 3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9215]
Xenopus
POU class 3 homeobox 2
XB-GENE-483174
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Pig
POU class 3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9215]
Opossum
POU class 3 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9215]
Xenopus
POU class 3 homeobox 2
Publication Statistics
PubMed Score 152.24
PubMed score by year
PubTator Score 174.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title