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Tbio
POU1F1
Pituitary-specific positive transcription factor 1

Protein Summary
Description
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202). This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344265
  • ENSP00000342931
  • ENSG00000064835
  • ENST00000350375
  • ENSP00000263781

Symbol
  • GHF1
  • PIT1
  • PIT1
  • CPHD1
  • GHF-1
  • Pit-1
  • POU1F1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
biological process
0.89
gene perturbation
0.76
tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.22   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.22   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
PROP1
Tbio
Family:  TF
Novelty:  0.00510395
Score:  0.924
Data Source:  STRINGDB
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
Score:  0.9
Data Source:  STRINGDB
TSHB
Tbio
Novelty:  0.00194403
Score:  0.889
Data Source:  STRINGDB
LHX3
Tbio
Family:  TF
Novelty:  0.00784158
Score:  0.885
Data Source:  STRINGDB
PRL
Tbio
Novelty:  0.0000905
Score:  0.852
Data Source:  STRINGDB
HESX1
Tbio
Family:  TF
Novelty:  0.00806405
Score:  0.851
Data Source:  STRINGDB
GHRHR
Tclin
Family:  GPCR
Novelty:  0.00637611
Score:  0.848
Data Source:  STRINGDB
TBX19
Tbio
Family:  TF
Novelty:  0.01599679
Score:  0.847
Data Source:  STRINGDB
CGA
Tbio
Novelty:  0.00394017
Score:  0.817
Data Source:  STRINGDB
ESX1
Tbio
Family:  TF
Novelty:  0.00330753
Score:  0.804
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
17.1
1
1
0
1.1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
17.1
0
1.1
10.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 1 homeobox 1
VGNC:12128
470861
Macaque
POU class 1 homeobox 1
719349
Mouse
MGI:97588
18736
Rat
RGD:3367
25517
Dog
POU class 1 homeobox 1
VGNC:44824
403753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 1 homeobox 1
Macaque
POU class 1 homeobox 1
Mouse
Rat
Dog
POU class 1 homeobox 1
Publication Statistics
PubMed Score 217.22
PubMed score by year
PubTator Score 422.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title