Tbio POP4 Ribonuclease P protein subunit p29

Protein Summary

Description

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P. This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• O95707
• Q5XKL7
• Q6FHW9
• Q9UQQ3
• hPOP4

Gene Name

• POP4

Ensembl ID

• ENST00000585603
• ENSP00000465213
• ENSG00000105171

Symbol

• RPP29
• RPP29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
disease perturbation	0.87
kinase perturbation	0.84
interacting protein	0.81
transcription factor binding site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.68   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.68   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (123)

Explore Interacting Targets

1 – 10 of 123

• See Interactions on String-DB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.999999999

p_ni:  1e-9

Score:  0.827

Data Source:  BioPlex,STRINGDB

RPP25

Tbio

Family:  Enzyme

Novelty:  0.07178063

p_int:  0.999999994

p_ni:  6e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP30

Tbio

Family:  Enzyme

Novelty:  0.01375777

p_int:  0.999999059

p_ni:  9.41e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPP40

Tbio

Family:  Enzyme

Novelty:  0.05981624

p_int:  0.999992282

p_ni:  0.000007718

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP21

Tbio

Family:  Enzyme

Novelty:  0.05805689

p_int:  0.999970504

p_ni:  0.000029398

p_wrong:  9.8e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPP14

Tbio

Family:  Enzyme

Novelty:  0.10813341

p_int:  0.999967821

p_ni:  0.000020738

p_wrong:  0.000011441

Score:  0.998

Data Source:  BioPlex,STRINGDB

POP7

Tbio

Family:  Enzyme

Novelty:  0.05460002

p_int:  0.999962974

p_ni:  0.000037026

Score:  0.996

Data Source:  BioPlex,STRINGDB

RPP25L

Tdark

Family:  Enzyme

Novelty:  1.39761189

p_int:  0.999957167

p_ni:  0.000042832

p_wrong:  2e-9

Score:  0.984

Data Source:  BioPlex,STRINGDB

RPP38

Tbio

Family:  Enzyme

Novelty:  0.06387902

p_int:  0.999778165

p_ni:  0.000221835

Score:  0.999

Data Source:  BioPlex,STRINGDB

POP5

Tbio

Family:  Enzyme

Novelty:  0.02459167

p_int:  0.999749574

p_ni:  0.000094876

p_wrong:  0.000155551

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (3)

KEGG (2)

Metabolism of RNA (R-HSA-8953854)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	tRNA processing	123 targets	R-HSA-72306
Reactome	tRNA processing in the nucleus	58 targets	R-HSA-6784531

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
tRNA processing	123 targets	R-HSA-72306
tRNA processing in the nucleus	58 targets	R-HSA-6784531

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (5)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
ribonuclease P RNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ribonuclease P activity	Traceable Author Statement (TAS)	ProtInc
RNA binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heart rate response to exercise	EFO_0009184	2	2	2		40.6
soluble triggering receptor expressed on myeloid cells 2 measurement	EFO_0010151	1	1	0	9196.5	24.5
heart rate response to recovery post exercise	EFO_0009185	2	1	2		7.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heart rate response to exercise	EFO_0009184	2		40.6
soluble triggering receptor expressed on myeloid cells 2 measurement	EFO_0010151	0	9196.5	24.5
heart rate response to recovery post exercise	EFO_0009185	2		7.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Direct protein sequencing
Hydrolase
Nucleus
Phosphoprotein
Reference proteome
tRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
heart rate response to exercise
heart rate response to recovery post exercise
soluble triggering receptor expressed on myeloid cells 2 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	POP4 homolog, ribonuclease P/MRP subunit	VGNC:2282	456386
Macaque	POP4 homolog, ribonuclease P/MRP subunit		700209
Mouse	processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)	MGI:1913411	66161
Rat	POP4 homolog, ribonuclease P/MRP subunit	RGD:1305955	292831
Dog	POP4 homolog, ribonuclease P/MRP subunit	VGNC:44816	612732

Species	Name	OMA	EggNOG	Inparanoid
Chimp	POP4 homolog, ribonuclease P/MRP subunit
Macaque	POP4 homolog, ribonuclease P/MRP subunit
Mouse	processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
Rat	POP4 homolog, ribonuclease P/MRP subunit
Dog	POP4 homolog, ribonuclease P/MRP subunit

Publication Statistics

PubMed Score 86.68

PubMed score by year

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PubTator Score 32.99

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (5)

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PMID	Year	Title