Tbio POP1 Ribonucleases P/MRP protein subunit POP1

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q99575
• A8K5W9
• Q15037
• hPOP1

Gene Name

• POP1

Ensembl ID

• ENST00000349693
• ENSP00000339529
• ENSG00000104356
• ENST00000401707
• ENSP00000385787

Symbol

• KIAA0061
• ANXD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.89
interacting protein	0.87
hub protein	0.75
cellular component	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.32   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (94)

Explore Interacting Targets

1 – 10 of 94

• See Interactions on String-DB

POP5

Tbio

Family:  Enzyme

Novelty:  0.02459167

p_int:  0.999829449

p_ni:  0.000170551

Score:  0.995

Data Source:  BioPlex,STRINGDB

RPP21

Tbio

Family:  Enzyme

Novelty:  0.05805689

p_int:  0.999798394

p_ni:  0.000201606

Score:  0.985

Data Source:  BioPlex,STRINGDB

RPP25L

Tdark

Family:  Enzyme

Novelty:  1.39761189

p_int:  0.999729081

p_ni:  0.000270919

Score:  0.821

Data Source:  BioPlex,STRINGDB

RPP30

Tbio

Family:  Enzyme

Novelty:  0.01375777

p_int:  0.999545488

p_ni:  0.000454512

Score:  0.995

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999405618

p_ni:  0.000594382

Score:  0.996

Data Source:  BioPlex,STRINGDB

RPP25

Tbio

Family:  Enzyme

Novelty:  0.07178063

p_int:  0.998933463

p_ni:  0.001066535

p_wrong:  1e-9

Score:  0.968

Data Source:  BioPlex,STRINGDB

NEPRO

Tbio

Novelty:  0.12980261

p_int:  0.994294283

p_ni:  0.005705717

Score:  0.161

Data Source:  BioPlex,STRINGDB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.992963807

p_ni:  0.007036193

Score:  0.768

Data Source:  BioPlex,STRINGDB

RBM4

Tbio

Novelty:  0.02034191

p_int:  0.958236547

p_ni:  0.041763453

Score:  0.154

Data Source:  BioPlex,STRINGDB

NIFK

Tbio

Novelty:  0.01221562

p_int:  0.915431245

p_ni:  0.084568755

Score:  0.178

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (3)

KEGG (2)

Metabolism of RNA (R-HSA-8953854)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	tRNA processing	123 targets	R-HSA-72306
Reactome	tRNA processing in the nucleus	58 targets	R-HSA-6784531

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
tRNA processing	123 targets	R-HSA-72306
tRNA processing in the nucleus	58 targets	R-HSA-6784531

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (3)

Components (6)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
ribonuclease MRP activity	Inferred from Direct Assay (IDA)	UniProtKB
ribonuclease P activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Disease mutation
Dwarfism
Hydrolase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
tRNA processing

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	POP1 homolog, ribonuclease P/MRP subunit	VGNC:8182	464303
Mouse	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	MGI:1914974	67724
Rat	POP1 homolog, ribonuclease P/MRP subunit	RGD:1308609	315045
Dog	POP1 homolog, ribonuclease P/MRP subunit	VGNC:44815	481978
Horse	POP1 homolog, ribonuclease P/MRP subunit	VGNC:21697	100055680

Species	Name	OMA	EggNOG	Inparanoid
Chimp	POP1 homolog, ribonuclease P/MRP subunit
Mouse	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Rat	POP1 homolog, ribonuclease P/MRP subunit
Dog	POP1 homolog, ribonuclease P/MRP subunit
Horse	POP1 homolog, ribonuclease P/MRP subunit

Publication Statistics

PubMed Score 0.32

PubMed score by year

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PubTator Score 29.91

PubTator score by year

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Related Publications

Text Mined References (28)

GeneRif Annotations (9)

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10

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PMID	Year	Title