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Tbio
PON3
Serum paraoxonase/lactonase 3

Protein Summary
Description
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265627
  • ENSP00000265627
  • ENSG00000105852
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.67
kinase perturbation
0.66
histone modification site profile
0.61
disease perturbation
0.56
biological term
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.21   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.21   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
NFYC
Tbio
Family:  TF
Novelty:  0.00626931
p_int:  0.997157835
p_ni:  0.000116564
p_wrong:  0.002725601
Score:  0.84
Data Source:  BioPlex,STRINGDB
PON1
Tbio
Family:  Enzyme
Novelty:  0.00033137
p_int:  0.99707541
p_ni:  2e-9
p_wrong:  0.002924588
Score:  0.939
Data Source:  BioPlex,STRINGDB
PDK4
Tchem
Family:  Kinase
Novelty:  0.00410067
Score:  0.656
Data Source:  STRINGDB
HMGCR
Tclin
Family:  Enzyme
Novelty:  0.00046789
Score:  0.652
Data Source:  STRINGDB
HMCN2
Tdark
Novelty:  0.27717122
Score:  0.644
Data Source:  STRINGDB
CES3
Tbio
Family:  Enzyme
Novelty:  0.00938734
Score:  0.56
Data Source:  STRINGDB
CES5A
Tbio
Family:  Enzyme
Novelty:  0.01165906
Score:  0.559
Data Source:  STRINGDB
DHX40
Tdark
Family:  Enzyme
Novelty:  0.27906444
Score:  0.549
Data Source:  STRINGDB
CES2
Tchem
Family:  Enzyme
Novelty:  0.00177726
Score:  0.545
Data Source:  STRINGDB
PPP1R9A
Tbio
Novelty:  0.04851082
Score:  0.542
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of 5-eicosatetraenoic acids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of 5-eicosatetraenoic acids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
2
91.6
high density lipoprotein cholesterol measurement
25
7
25
83.5
aspartate aminotransferase, cytoplasmic measurement
1
2
2
72.3
leucine carboxyl methyltransferase 1 measurement
1
1
1
53.3
phospholipids:total lipids ratio
2
2
2
52.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
91.6
high density lipoprotein cholesterol measurement
25
83.5
aspartate aminotransferase, cytoplasmic measurement
2
72.3
leucine carboxyl methyltransferase 1 measurement
1
53.3
phospholipids:total lipids ratio
2
52.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
paraoxonase 3
699236
Mouse
MGI:106686
269823
Rat
RGD:1302965
312086
Dog
paraoxonase 3
VGNC:44814
475235
Horse
paraoxonase 3
VGNC:21696
100051959
Species
Name
OMA
EggNOG
Inparanoid
Macaque
paraoxonase 3
Mouse
Rat
Dog
paraoxonase 3
Horse
paraoxonase 3
Publication Statistics
PubMed Score 128.21
PubMed score by year
PubTator Score 84.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title