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Tbio
PON2
Serum paraoxonase/arylesterase 2

Protein Summary
Description
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222572
  • ENSP00000222572
  • ENSG00000105854
  • ENST00000433091
  • ENSP00000404622
  • ENST00000633531
  • ENSP00000488838
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
disease perturbation
0.93
virus perturbation
0.88
histone modification site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
ABCA2
Tbio
Family:  Transporter
Novelty:  0.02208136
p_int:  0.999782765
p_ni:  0.000217198
p_wrong:  3.7e-8
Score:  0.224
Data Source:  BioPlex,STRINGDB
ST3GAL6
Tbio
Family:  Enzyme
Novelty:  0.05226811
p_int:  0.999765792
p_ni:  0.000231387
p_wrong:  0.000002822
Data Source:  BioPlex
CTSF
Tchem
Family:  Enzyme
Novelty:  0.01359417
p_int:  0.999425958
p_ni:  0.000573966
p_wrong:  7.6e-8
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.995494913
p_ni:  0.00450508
p_wrong:  6e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
C1QL4
Tdark
Novelty:  0.37071722
p_int:  0.994489395
p_ni:  0.005510605
Score:  0.173
Data Source:  BioPlex,STRINGDB
SLC39A11
Tbio
Family:  Transporter
Novelty:  0.09770302
p_int:  0.992654216
p_ni:  0.007345784
Data Source:  BioPlex
HYAL2
Tbio
Family:  Enzyme
Novelty:  0.00740331
p_int:  0.990867066
p_ni:  0.009132934
Data Source:  BioPlex
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.986294043
p_ni:  0.013705946
p_wrong:  1.1e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
ITGA4
Tclin
Novelty:  0.00197607
p_int:  0.983720088
p_ni:  0.016279912
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.981129237
p_ni:  0.018870763
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of 5-eicosatetraenoic acids
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of 5-eicosatetraenoic acids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
2
53.1
mathematical ability
2
1
2
49.5
apolipoprotein A 1 measurement
2
1
2
38.8
self reported educational attainment
1
1
1
33.1
stem Cell Factor measurement
1
1
1
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
53.1
mathematical ability
2
49.5
apolipoprotein A 1 measurement
2
38.8
self reported educational attainment
1
33.1
stem Cell Factor measurement
1
32.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paraoxonase 2
VGNC:4473
463549
Macaque
paraoxonase 2
699107
Mouse
MGI:106687
330260
Rat
RGD:1309954
296851
Dog
paraoxonase 2
VGNC:44813
403855
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paraoxonase 2
Macaque
paraoxonase 2
Mouse
Rat
Dog
paraoxonase 2
Publication Statistics
PubMed Score 244.00
PubMed score by year
PubTator Score 170.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title