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Tbio
POMT2
Protein O-mannosyl-transferase 2

Protein Summary
Description
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS).[provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261534
  • ENSP00000261534
  • ENSG00000009830
  • ENST00000556326
  • ENSP00000450630

Symbol
  • LGMD2N
  • MDDGA2
  • MDDGB2
  • MDDGC2
  • LGMDR14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
small molecule perturbation
0.7
tissue sample
0.66
phenotype
0.65
transcription factor
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.26   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.26   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
CD244
Tbio
Novelty:  0.01137579
p_int:  0.999986366
p_ni:  0.000013634
Data Source:  BioPlex
RFTN2
Tdark
Novelty:  0.99330616
p_int:  0.999864996
p_ni:  0.000135004
Score:  0.158
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.995271571
p_ni:  0.004728429
Data Source:  BioPlex
TMEM92
Tdark
Novelty:  0.72258983
p_int:  0.953800894
p_ni:  0.046199106
Score:  0.167
Data Source:  BioPlex,STRINGDB
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.952638228
p_ni:  0.047361772
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.944588063
p_ni:  0.055411937
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.933079344
p_ni:  0.066920656
Score:  0.179
Data Source:  BioPlex,STRINGDB
APOC3
Tclin
Novelty:  0.0009635
p_int:  0.929473975
p_ni:  0.070526025
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.924436208
p_ni:  0.075563792
Data Source:  BioPlex
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.90701309
p_ni:  0.09298691
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 (R-HSA-5083633)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1
Reactome
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
81
myeloid white cell count
2
2
2
74.7
leukocyte count
2
2
2
67.5
granulocyte count
1
1
1
54.4
sum of basophil and neutrophil counts
1
1
1
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
81
myeloid white cell count
2
74.7
leukocyte count
2
67.5
granulocyte count
1
54.4
sum of basophil and neutrophil counts
1
51.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein O-mannosyltransferase 2
VGNC:7451
453067
Macaque
protein O-mannosyltransferase 2
705604
Mouse
MGI:2444430
217734
Rat
RGD:1586427
688673
Dog
protein O-mannosyltransferase 2
VGNC:44811
480400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein O-mannosyltransferase 2
Macaque
protein O-mannosyltransferase 2
Mouse
Rat
Dog
protein O-mannosyltransferase 2
Publication Statistics
PubMed Score 42.26
PubMed score by year
PubTator Score 38.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title