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Tbio
POMP
Proteasome maturation protein

Protein Summary
Description
Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380842
  • ENSP00000370222
  • ENSG00000132963

Symbol
  • C13orf12
  • UMP1
  • UMP1
  • PRAAS2
  • HSPC014
  • C13orf12
  • PNAS-110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.8
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.18   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.18   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.955
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.999999803
p_ni:  1.97e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
PSMB7
Tbio
Family:  Enzyme
Novelty:  0.06547657
p_int:  0.999995448
p_ni:  0.000004552
Score:  0.978
Data Source:  BioPlex,STRINGDB
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
p_int:  0.999995261
p_ni:  0.000004739
Score:  0.997
Data Source:  BioPlex,STRINGDB
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
p_int:  0.99999271
p_ni:  0.00000729
Score:  0.991
Data Source:  BioPlex,STRINGDB
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.999973168
p_ni:  0.000026832
Score:  0.982
Data Source:  BioPlex,STRINGDB
PSMB2
Tclin
Family:  Enzyme
Novelty:  0.06714761
p_int:  0.99993275
p_ni:  0.00006725
Score:  0.995
Data Source:  BioPlex,STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
p_int:  0.999749335
p_ni:  0.000250665
Score:  0.992
Data Source:  BioPlex,STRINGDB
PSMB4
Tbio
Family:  Enzyme
Novelty:  0.0376233
p_int:  0.999655733
p_ni:  0.000344267
Score:  0.995
Data Source:  BioPlex,STRINGDB
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999646532
p_ni:  0.000353428
p_wrong:  4e-8
Score:  0.232
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
2
3
84.1
hematocrit
3
1
3
40.6
red blood cell density measurement
1
1
1
38.7
fetal genotype effect measurement
1
1
0
1.2
12.3
1
1
0
1.2
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
84.1
hematocrit
3
40.6
red blood cell density measurement
1
38.7
fetal genotype effect measurement
0
1.2
12.3
0
1.2
12.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome maturation protein
VGNC:13128
737989
Mouse
MGI:1913787
66537
Rat
RGD:6494524
100911238
Horse
proteasome maturation protein [Source:HGNC Symbol;Acc:HGNC:20330]
Cow
proteasome maturation protein
VGNC:33157
510314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome maturation protein
Mouse
Rat
Horse
proteasome maturation protein [Source:HGNC Symbol;Acc:HGNC:20330]
Cow
proteasome maturation protein
Publication Statistics
PubMed Score 58.18
PubMed score by year
PubTator Score 80.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title