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Tbio
POMK
Protein O-mannose kinase

Protein Summary
Description
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331373
  • ENSP00000331258
  • ENSG00000185900
  • ENST00000614426
  • ENSP00000478821

Symbol
  • SGK196
  • SGK196
  • MDDGA12
  • MDDGC12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
histone modification site profile
0.79
tissue sample
0.66
cell line
0.61
transcription factor binding site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
PKDCC
Tbio
Family:  Kinase
Novelty:  0.02347112
p_int:  0.999998465
p_ni:  4.92e-7
p_wrong:  0.000001043
Score:  0.637
Data Source:  BioPlex,STRINGDB
BRIP1
Tbio
Novelty:  0.03886334
p_int:  0.999975509
p_ni:  0.000024491
Data Source:  BioPlex
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.999967392
p_ni:  0.000032608
Data Source:  BioPlex
LETMD1
Tbio
Novelty:  0.02790517
p_int:  0.999958568
p_ni:  0.000041432
Data Source:  BioPlex
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.999934942
p_ni:  0.000065058
Data Source:  BioPlex
TMEM120A
Tdark
Novelty:  0.21664358
p_int:  0.999893652
p_ni:  0.000095692
p_wrong:  0.000010655
Score:  0.509
Data Source:  BioPlex,STRINGDB
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999354976
p_ni:  0.000575836
p_wrong:  0.000069188
Data Source:  BioPlex
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.9993318
p_ni:  0.0006682
Score:  0.199
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.999273004
p_ni:  0.000726996
Data Source:  BioPlex
USP30
Tchem
Family:  Enzyme
Novelty:  0.03427211
p_int:  0.998840717
p_ni:  0.001159203
p_wrong:  8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein-O-mannose kinase
VGNC:13229
464154
Macaque
protein-O-mannose kinase
706318
Mouse
MGI:1921903
74653
Rat
RGD:1310810
306549
Dog
protein-O-mannose kinase
VGNC:44809
482834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein-O-mannose kinase
Macaque
protein-O-mannose kinase
Mouse
Rat
Dog
protein-O-mannose kinase
Publication Statistics
PubMed Score 12.01
PubMed score by year
PubTator Score 6.60
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title