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Tbio
POMC
Pro-opiomelanocortin

Protein Summary
Description
Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate. This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264708
  • ENSP00000264708
  • ENSG00000115138
  • ENST00000380794
  • ENSP00000370171
  • ENST00000395826
  • ENSP00000379170
  • ENST00000405623
  • ENSP00000384092

Symbol
  • LPH
  • MSH
  • NPP
  • POC
  • ACTH
  • CLIP
  • OBAIRH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
disease
0.75
biological process
0.74
cellular component
0.7
biological term
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44550.22   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 2232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44550.22   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 2232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0