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Tbio
POLR3K
DNA-directed RNA polymerase III subunit RPC10

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293860
  • ENSP00000293860
  • ENSG00000161980

Symbol
  • RPC11
  • C11
  • My010
  • RPC10
  • RPC11
  • RPC12.5
  • C11-RNP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.84
disease perturbation
0.74
transcription factor binding site profile
0.73
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3G
Tbio
Family:  Enzyme
Novelty:  0.04923071
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.927
Data Source:  BioPlex,STRINGDB
POLR3H
Tbio
Family:  Enzyme
Novelty:  0.16483597
p_int:  0.999999947
p_ni:  5.3e-8
Score:  0.989
Data Source:  BioPlex,STRINGDB
CRCP
Tbio
Family:  Enzyme
Novelty:  0.01111812
p_int:  0.999998757
p_ni:  0.000001242
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
p_int:  0.999998301
p_ni:  0.000001699
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR3B
Tbio
Family:  Enzyme
Novelty:  0.02526167
p_int:  0.999996781
p_ni:  0.000003219
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.9999942
p_ni:  0.000005686
p_wrong:  1.15e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3GL
Tdark
Family:  Enzyme
Novelty:  0.35648533
p_int:  0.999991052
p_ni:  0.000004955
p_wrong:  0.000003993
Score:  0.982
Data Source:  BioPlex,STRINGDB
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
p_int:  0.999981498
p_ni:  0.000018502
Score:  0.998
Data Source:  BioPlex,STRINGDB
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.999963344
p_ni:  0.000036652
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
6
7
8
99.6
mean corpuscular volume
3
4
6
97.5
erythrocyte count
4
5
6
95.5
reticulocyte measurement
2
4
5
92.4
mean reticulocyte volume
1
2
2
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
8
99.6
mean corpuscular volume
6
97.5
erythrocyte count
6
95.5
reticulocyte measurement
5
92.4
mean reticulocyte volume
2
91.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit K
VGNC:8995
744386
Macaque
RNA polymerase III subunit K
100423709
Mouse
MGI:1914255
67005
Rat
RGD:1587294
366277
Dog
RNA polymerase III subunit K
VGNC:44807
106558946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit K
Macaque
RNA polymerase III subunit K
Mouse
Rat
Dog
RNA polymerase III subunit K
Publication Statistics
PubMed Score 13.01
PubMed score by year
PubTator Score 533.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title