POLR3G
DNA-directed RNA polymerase III subunit RPC7
Protein Summary
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (PubMed:20154270). May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa- ...more
- ENST00000399107
- ENSP00000382058
- ENSG00000113356
- ENST00000504930
- ENSP00000421637
- RPC7
- RPC32
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
gene perturbation | 0.76 | ||
histone modification site profile | 0.76 | ||
disease perturbation | 0.74 | ||
biological process | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.41 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 106 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.41 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 106 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (105)
POLR3K
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
POLR1C
Family: Enzyme
Novelty: 0.04485332
p_int: 0.999999938
p_ni: 1.9e-8
p_wrong: 4.3e-8
Score: 0.991
Data Source: BioPlex,STRINGDB
POLR3E
Family: Enzyme
Novelty: 0.06500715
p_int: 0.99999489
p_ni: 0.000004084
p_wrong: 0.000001026
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3D
Family: Enzyme
Novelty: 0.02616321
p_int: 0.99999467
p_ni: 6e-9
p_wrong: 0.000005324
Score: 0.994
Data Source: BioPlex,STRINGDB
POLR2E
Family: Enzyme
Novelty: 0.01817288
p_int: 0.999977607
p_ni: 0.000022384
p_wrong: 9e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
EFEMP1
Novelty: 0.00574779
p_int: 0.996327916
p_ni: 0.000555764
p_wrong: 0.00311632
Score: 0.175
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (12)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytosolic sensors of pathogen-associated DNA | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | RNA Polymerase III Abortive And Retractive Initiation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytosolic sensors of pathogen-associated DNA | ||||
Gene expression (Transcription) | ||||
Immune System | ||||
Innate Immune System | ||||
RNA Polymerase III Abortive And Retractive Initiation | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | RNA polymerase III subunit G | VGNC:8632 | 461759 | |||||
Macaque | RNA polymerase III subunit G | 695330 | ||||||
Mouse | MGI:1914736 | 67486 | ||||||
Rat | RGD:1593792 | 685465 | ||||||
Dog | RNA polymerase III subunit G | VGNC:44805 | 609731 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | RNA polymerase III subunit G | |||||
Macaque | RNA polymerase III subunit G | |||||
Mouse | ||||||
Rat | ||||||
Dog | RNA polymerase III subunit G | |||||
Publication Statistics
PubMed Score 22.41
PubMed score by year
PubTator Score 6.65
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (3)
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PMID | Year | Title |
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