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Tbio
POLR3E
DNA-directed RNA polymerase III subunit RPC5

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299853
  • ENSP00000299853
  • ENSG00000058600
  • ENST00000359210
  • ENSP00000352140
  • ENST00000418581
  • ENSP00000399254
  • ENST00000564209
  • ENSP00000456967
  • ENST00000638476
  • ENSP00000492534
  • ENSG00000284282
  • ENST00000638525
  • ENSP00000492639
  • ENST00000639149
  • ENSP00000492586
  • ENST00000640588
  • ENSP00000492263

Symbol
  • KIAA1452
  • SIN
  • RPC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
kinase perturbation
0.91
interacting protein
0.89
transcription factor perturbation
0.8
histone modification site profile
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
71.1
heel bone mineral density
2
2
2
71.1
body height
1
1
1
42.3
body height
1
1
1
42.3
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
71.1
heel bone mineral density
2
71.1
body height
1
42.3
body height
1
42.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit E
VGNC:8994
454351
Macaque
RNA polymerase III subunit E
697901
Mouse
MGI:1349452
26939
Rat
RGD:1308086
361640
Dog
RNA polymerase III subunit E
VGNC:54059
608689
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit E
Macaque
RNA polymerase III subunit E
Mouse
Rat
Dog
RNA polymerase III subunit E
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NVU0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (144)
1 – 10 of 144
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
POLR3GL
Tdark
Family:  Enzyme
Novelty:  0.35648533
p_int:  0.999999897
p_ni:  1.03e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.99999978
p_ni:  2.2e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.999998952
p_ni:  0.000001048
Score:  0.69
Data Source:  BioPlex,STRINGDB
POLR3G
Tbio
Family:  Enzyme
Novelty:  0.04923071
p_int:  0.99999489
p_ni:  0.000004084
p_wrong:  0.000001026
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3H
Tbio
Family:  Enzyme
Novelty:  0.16483597
p_int:  0.999994841
p_ni:  0.00000468
p_wrong:  4.8e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3F
Tbio
Family:  Enzyme
Novelty:  0.0805125
p_int:  0.999964292
p_ni:  0.000035699
p_wrong:  8e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
p_int:  0.999955885
p_ni:  0.000044114
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.999924206
p_ni:  0.000075794
Score:  0.998
Data Source:  BioPlex,STRINGDB
POLR3B
Tbio
Family:  Enzyme
Novelty:  0.02526167
p_int:  0.99991543
p_ni:  0.00008457
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.54

PubMed score by year
PubTator Score  67.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer