Tbio POLR3E DNA-directed RNA polymerase III subunit RPC5

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase Iii Subunit Rpc5

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase Iii Subunit Rpc5

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Uniprot Accession IDs

• Q9NVU0
• B4DL24
• B4DUP6
• H3BT11
• Q9BWF7
• Q9H8W8
• Q9H907
• Q9P276
• RNA polymerase III subunit C5

Gene Name

• POLR3E

Ensembl ID

• ENST00000299853
• ENSP00000299853
• ENSG00000058600
• ENST00000359210
• ENSP00000352140
• ENST00000418581
• ENSP00000399254
• ENST00000564209
• ENSP00000456967
• ENST00000638476
• ENSP00000492534
• ENSG00000284282
• ENST00000638525
• ENSP00000492639
• ENST00000639149
• ENSP00000492586
• ENST00000640588
• ENSP00000492263

Symbol

• KIAA1452
• SIN
• RPC5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
kinase perturbation	0.91
interacting protein	0.89
transcription factor perturbation	0.8
histone modification site profile	0.75

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.54   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

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5

1 – 4 of 4

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	ENSG00000058600	2	2	2		71.1
heel bone mineral density	EFO_0009270	ENSG00000284282	2	2	2		71.1
body height	EFO_0004339	ENSG00000284282	1	1	1		42.3
body height	EFO_0004339	ENSG00000058600	1	1	1		42.3

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		71.1
heel bone mineral density	EFO_0009270	2		71.1
body height	EFO_0004339	1		42.3
body height	EFO_0004339	1		42.3

Reset Zoom  Beta Count   Odds Ratio

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RNA polymerase III subunit E	VGNC:8994	454351
Macaque	RNA polymerase III subunit E		697901
Mouse	polymerase (RNA) III (DNA directed) polypeptide E	MGI:1349452	26939
Rat	RNA polymerase III subunit E	RGD:1308086	361640
Dog	RNA polymerase III subunit E	VGNC:54059	608689

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RNA polymerase III subunit E
Macaque	RNA polymerase III subunit E
Mouse	polymerase (RNA) III (DNA directed) polypeptide E
Rat	RNA polymerase III subunit E
Dog	RNA polymerase III subunit E

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9NVU0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)

Reactome (12)

KEGG (2)

WikiPathways (3)

Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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Find Similar Targets

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1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	RNA Polymerase III Abortive And Retractive Initiation	42 targets	R-HSA-749476

Name	Explore in Pharos	Explore in Source
Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Gene expression (Transcription)	1452 targets	R-HSA-74160
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
RNA Polymerase III Abortive And Retractive Initiation	42 targets	R-HSA-749476

Gene Ontology Terms (8)

Functions (1)

Components (4)

Processes (3)

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1 – 1 of 1

GO Term	Evidence	Assigned by
DNA-directed 5'-3' RNA polymerase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (144)

Explore Interacting Targets

1 – 10 of 144

• See Interactions on String-DB

POLR3D

Tbio

Family:  Enzyme

Novelty:  0.02616321

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

POLR3GL

Tdark

Family:  Enzyme

Novelty:  0.35648533

p_int:  0.999999897

p_ni:  1.03e-7

Score:  0.985

Data Source:  BioPlex,STRINGDB

POLR1C

Tbio

Family:  Enzyme

Novelty:  0.04485332

p_int:  0.99999978

p_ni:  2.2e-7

Score:  0.997

Data Source:  BioPlex,STRINGDB

GPN3

Tbio

Family:  Enzyme

Novelty:  0.13817794

p_int:  0.999998952

p_ni:  0.000001048

Score:  0.69

Data Source:  BioPlex,STRINGDB

POLR3G

Tbio

Family:  Enzyme

Novelty:  0.04923071

p_int:  0.99999489

p_ni:  0.000004084

p_wrong:  0.000001026

Score:  0.999

Data Source:  BioPlex,STRINGDB

POLR3H

Tbio

Family:  Enzyme

Novelty:  0.16483597

p_int:  0.999994841

p_ni:  0.00000468

p_wrong:  4.8e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

POLR3F

Tbio

Family:  Enzyme

Novelty:  0.0805125

p_int:  0.999964292

p_ni:  0.000035699

p_wrong:  8e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

POLR3C

Tbio

Family:  Enzyme

Novelty:  0.05778457

p_int:  0.999955885

p_ni:  0.000044114

Score:  0.999

Data Source:  BioPlex,STRINGDB

POLR2E

Tbio

Family:  Enzyme

Novelty:  0.01817288

p_int:  0.999924206

p_ni:  0.000075794

Score:  0.998

Data Source:  BioPlex,STRINGDB

POLR3B

Tbio

Family:  Enzyme

Novelty:  0.02526167

p_int:  0.99991543

p_ni:  0.00008457

Score:  0.999

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  15.54

PubMed score by year

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PubTator Score  67.29

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Antiviral defense
Complete proteome
DNA-directed RNA polymerase
Immunity
Innate immunity
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
body height
heel bone mineral density