Tbio POLR3E DNA-directed RNA polymerase III subunit RPC5

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

Uniprot Accession IDs

• Q9NVU0
• B4DL24
• B4DUP6
• H3BT11
• Q9BWF7
• Q9H8W8
• Q9H907
• Q9P276
• RNA polymerase III subunit C5

Gene Name

• POLR3E

Ensembl ID

• ENST00000299853
• ENSP00000299853
• ENSG00000058600
• ENST00000359210
• ENSP00000352140
• ENST00000418581
• ENSP00000399254
• ENST00000564209
• ENSP00000456967
• ENST00000638476
• ENSP00000492534
• ENSG00000284282
• ENST00000638525
• ENSP00000492639
• ENST00000639149
• ENSP00000492586
• ENST00000640588
• ENSP00000492263

Symbol

• KIAA1452
• SIN
• RPC5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
kinase perturbation	0.91
interacting protein	0.89
transcription factor perturbation	0.8
histone modification site profile	0.75

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase Iii Subunit Rpc5

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase Iii Subunit Rpc5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.53   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.53   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0