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Tbio
POLR2L
DNA-directed RNA polymerases I, II, and III subunit RPABC5

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322028
  • ENSP00000324124
  • ENSG00000177700
  • ENST00000534030
  • ENSP00000432807

Symbol
  • RBP10
  • RPB10
  • RPABC5
  • RPB7.6
  • hRPB7.6
  • RPB10beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
biological process
0.88
molecular function
0.73
histone modification site profile
0.64
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (651)
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.996578911
p_ni:  0.003421077
p_wrong:  1.2e-8
Score:  0.97
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.994841499
p_ni:  0.005158497
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
GPN1
Tbio
Family:  Enzyme
Novelty:  0.06883613
p_int:  0.994770018
p_ni:  0.003035705
p_wrong:  0.002194277
Score:  0.403
Data Source:  BioPlex,STRINGDB
GPN2
Tdark
Family:  Enzyme
Novelty:  0.26461894
p_int:  0.992551658
p_ni:  0.007448064
p_wrong:  2.79e-7
Score:  0.789
Data Source:  BioPlex,STRINGDB
POLR3K
Tbio
Family:  Enzyme
Novelty:  0.07105011
p_int:  0.992149073
p_ni:  0.007846301
p_wrong:  0.000004627
Score:  0.997
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.990953121
p_ni:  0.009045701
p_wrong:  0.000001178
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR3GL
Tdark
Family:  Enzyme
Novelty:  0.35648533
p_int:  0.989833709
p_ni:  0.01016629
p_wrong:  1e-9
Score:  0.957
Data Source:  BioPlex,STRINGDB
RCCD1
Tbio
Novelty:  0.07481641
p_int:  0.984764655
p_ni:  0.015035471
p_wrong:  0.000199874
Data Source:  BioPlex
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.98305898
p_ni:  0.016941009
p_wrong:  1.1e-8
Score:  0.689
Data Source:  BioPlex,STRINGDB
POLR3D
Tbio
Family:  Enzyme
Novelty:  0.02616321
p_int:  0.9824062
p_ni:  0.017593794
p_wrong:  5e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (98)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 91
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
B-WICH complex positively regulates rRNA expression
Cytosolic sensors of pathogen-associated DNA
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
91.5
mean platelet volume
2
2
2
89.4
intraocular pressure measurement
2
3
3
89
waist-hip ratio
4
6
9
86.9
2
2
1
6.6
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
91.5
mean platelet volume
2
89.4
intraocular pressure measurement
3
89
waist-hip ratio
9
86.9
1
6.6
82.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913741
66491
Horse
RNA polymerase II subunit L
VGNC:21683
100629865
Cow
RNA polymerase II subunit L
VGNC:33144
617375
Pig
DNA-directed RNA polymerases I, II, and III subunit RPABC5-like
102164011
Chicken
RNA polymerase II subunit L
CGNC:5165
770704
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
RNA polymerase II subunit L
Cow
RNA polymerase II subunit L
Pig
DNA-directed RNA polymerases I, II, and III subunit RPABC5-like
Chicken
RNA polymerase II subunit L
Publication Statistics
PubMed Score 26.64
PubMed score by year
PubTator Score 4.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title