You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POLR2J
DNA-directed RNA polymerase II subunit RPB11-a

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292614
  • ENSP00000292614
  • ENSG00000005075

Symbol
  • POLR2J1
  • RPB11
  • RPB11A
  • RPB11m
  • hRPB14
  • POLR2J1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
biological process
0.78
transcription factor binding site profile
0.71
pathway
0.7
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.52   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.52   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (575)
POLR2J2
Tdark
Family:  Enzyme
Novelty:  3.91016733
p_int:  1
Score:  0.802
Data Source:  BioPlex,STRINGDB
RPRD2
Tdark
Novelty:  0.45063764
p_int:  0.999999854
p_ni:  1.46e-7
Score:  0.903
Data Source:  BioPlex,STRINGDB
RECQL5
Tbio
Family:  Enzyme
Novelty:  0.01558497
p_int:  0.999999574
p_ni:  6.7e-8
p_wrong:  3.6e-7
Data Source:  BioPlex
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.999993187
p_ni:  0.000006813
Score:  0.987
Data Source:  BioPlex,STRINGDB
SUPT6H
Tbio
Novelty:  0.01099565
p_int:  0.999948659
p_ni:  0.000051341
Score:  0.909
Data Source:  BioPlex,STRINGDB
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  0.999910478
p_ni:  0.000089459
p_wrong:  6.3e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
RPRD1A
Tbio
Novelty:  0.13521196
p_int:  0.999905892
p_ni:  0.000094108
p_wrong:  1e-9
Score:  0.901
Data Source:  BioPlex,STRINGDB
RPAP1
Tbio
Family:  Enzyme
Novelty:  0.23737405
p_int:  0.999856264
p_ni:  0.000143736
Score:  0.896
Data Source:  BioPlex,STRINGDB
PHRF1
Tbio
Family:  Epigenetic
Novelty:  0.05250013
p_int:  0.999830001
p_ni:  0.000138083
p_wrong:  0.000031917
Data Source:  BioPlex
GPN2
Tdark
Family:  Enzyme
Novelty:  0.26461894
p_int:  0.999643802
p_ni:  0.00035617
p_wrong:  2.8e-8
Score:  0.803
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (74)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
DNA Repair
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
DNA Repair
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1.1
93.6
circadian rhythm
2
1
2
48
insomnia measurement
1
1
0
1.1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
93.6
circadian rhythm
2
48
insomnia measurement
0
1.1
30.9
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit J
100609886
Mouse
MGI:109582
20022
Rat
RGD:1310198
288588
Dog
RNA polymerase II subunit J
100686835
Horse
RNA polymerase II subunit J
100059695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit J
Mouse
Rat
Dog
RNA polymerase II subunit J
Horse
RNA polymerase II subunit J
Publication Statistics
PubMed Score 48.52
PubMed score by year
PubTator Score 7.86
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title