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Tbio
POLR1E
DNA-directed RNA polymerase I subunit RPA49

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377792
  • ENSP00000367023
  • ENSG00000137054
  • ENST00000377798
  • ENSP00000367029

Symbol
  • PAF53
  • PRAF1
  • PAF53
  • PRAF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
disease perturbation
0.79
transcription factor binding site profile
0.7
histone modification site profile
0.67
protein complex
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.26   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.26   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (338)
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.999999232
p_ni:  7.67e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
p_int:  0.999957746
p_ni:  0.000042254
Score:  0.996
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.9996288
p_ni:  0.0003712
Score:  0.991
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.999059782
p_ni:  0.00094006
p_wrong:  1.59e-7
Score:  0.253
Data Source:  BioPlex,STRINGDB
NFKBIB
Tbio
Novelty:  0.00517222
p_int:  0.997805855
p_ni:  0.002194109
p_wrong:  3.6e-8
Score:  0.265
Data Source:  BioPlex,STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.997468738
p_ni:  0.002531249
p_wrong:  1.2e-8
Data Source:  BioPlex
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.986958047
p_ni:  0.00943578
p_wrong:  0.003606173
Data Source:  BioPlex
TENT5A
Tbio
Novelty:  0.08412895
p_int:  0.981353269
p_ni:  0.018625795
p_wrong:  0.000020937
Data Source:  BioPlex
ZNF692
Tbio
Family:  TF
Novelty:  0.07012646
p_int:  0.980477013
p_ni:  0.019511107
p_wrong:  0.00001188
Score:  0.171
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.979472352
p_ni:  0.020483125
p_wrong:  0.000044523
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
1
1
0
32.5
24.5
daytime rest measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
0
32.5
24.5
daytime rest measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I subunit E
VGNC:9189
747551
Macaque
RNA polymerase I subunit E
716506
Mouse
MGI:1929022
64424
Rat
RGD:1565773
313245
Dog
RNA polymerase I subunit E
VGNC:44791
474767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I subunit E
Macaque
RNA polymerase I subunit E
Mouse
Rat
Dog
RNA polymerase I subunit E
Publication Statistics
PubMed Score 8.26
PubMed score by year
PubTator Score 7.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title