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Tbio
POLL
DNA polymerase lambda

Protein Summary
Description
DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10982892, PubMed:10887191, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299206
  • ENSP00000299206
  • ENSG00000166169
  • ENST00000370162
  • ENSP00000359181
  • ENST00000370169
  • ENSP00000359188
  • ENST00000628479
  • ENSP00000485885

Symbol
  • BETAN
  • POLKAPPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
histone modification site profile
0.91
cell type or tissue
0.68
small molecule perturbation
0.67
transcription factor
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 447.64   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 447.64   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
C9orf64
Tdark
Novelty:  0.66704146
p_int:  0.999999323
p_ni:  5e-9
p_wrong:  6.72e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
SEMG2
Tbio
Novelty:  0.06325799
p_int:  0.999985073
p_ni:  0.000014927
Score:  0.207
Data Source:  BioPlex,STRINGDB
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.999976911
p_ni:  0.000023089
Data Source:  BioPlex
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.995255474
p_ni:  0.004744508
p_wrong:  1.7e-8
Data Source:  BioPlex
SYN2
Tbio
Novelty:  0.00574709
p_int:  0.994685241
p_ni:  0.000005903
p_wrong:  0.005308856
Score:  0.187
Data Source:  BioPlex,STRINGDB
LTF
Tbio
Novelty:  0.00114254
p_int:  0.994555369
p_ni:  0.005444631
Score:  0.17
Data Source:  BioPlex,STRINGDB
SULT1C2
Tbio
Family:  Enzyme
Novelty:  0.02956075
p_int:  0.97605793
p_ni:  0.004872902
p_wrong:  0.019069168
Score:  0.237
Data Source:  BioPlex,STRINGDB
RIOX2
Tbio
Family:  Epigenetic
Novelty:  0.03254245
p_int:  0.970756155
p_ni:  0.029243845
Score:  0.167
Data Source:  BioPlex,STRINGDB
IGHA1
Tbio
p_int:  0.915319579
p_ni:  0.084680421
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.894259909
p_ni:  0.000052475
p_wrong:  0.105687617
Score:  0.186
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
DNA Double-Strand Break Repair (R-HSA-5693532)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Nonhomologous End-Joining (NHEJ)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Nonhomologous End-Joining (NHEJ)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
22.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase lambda
VGNC:8883
450687
Macaque
DNA polymerase lambda
711924
Mouse
MGI:1889000
56626
Rat
RGD:1308053
361767
Dog
DNA polymerase lambda
VGNC:44786
608341
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase lambda
Macaque
DNA polymerase lambda
Mouse
Rat
Dog
DNA polymerase lambda
Publication Statistics
PubMed Score 447.64
PubMed score by year
PubTator Score 153.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title