POLE4
DNA polymerase epsilon subunit 4
Protein Summary
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function. POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
- ENST00000483063
- ENSP00000420176
- ENSG00000115350
- p12
- YHHQ1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
histone modification site profile | 0.91 | ||
small molecule perturbation | 0.77 | ||
disease perturbation | 0.74 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.75 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 72 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.75 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 72 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (222)
POLE
Family: Enzyme
Novelty: 0.00371129
p_int: 0.999988876
p_ni: 0.000011125
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
POLE3
Family: Enzyme
Novelty: 0.09657513
p_int: 0.999931776
p_ni: 0.000066728
p_wrong: 0.000001497
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KAT14
Novelty: 0.17168043
p_int: 0.999905353
p_ni: 0.000094647
Score: 0.795
Data Source: BioPlex,STRINGDB
POLE2
Family: Enzyme
Novelty: 0.03129531
p_int: 0.999899453
p_ni: 0.000096883
p_wrong: 0.000003664
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
YEATS2
Novelty: 0.17584498
p_int: 0.999503708
p_ni: 0.000496292
Score: 0.887
Data Source: BioPlex,STRINGDB
ZZZ3
Family: TF
Novelty: 0.23862921
p_int: 0.999310667
p_ni: 0.000689328
p_wrong: 5e-9
Score: 0.36
Data Source: BioPlex,STRINGDB
MBIP
Novelty: 0.05807454
p_int: 0.998478455
p_ni: 0.001521472
p_wrong: 7.3e-8
Score: 0.906
Data Source: BioPlex,STRINGDB
GALNS
Family: Enzyme
Novelty: 0.00510529
p_int: 0.996907913
p_ni: 0.002992399
p_wrong: 0.000099688
Data Source: BioPlex
LIN7B
Novelty: 0.12689192
p_int: 0.968050008
p_ni: 0.022412954
p_wrong: 0.009537038
Data Source: BioPlex
TADA2A
Family: TF
Novelty: 0.07665459
p_int: 0.967073014
p_ni: 0.007396307
p_wrong: 0.025530679
Score: 0.655
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (6)
Upstream (3)
Downstream (3)
1 – 3 of 3
Pathways (39)
Reactome (35)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of the pre-replicative complex | ||||
Reactome | Base Excision Repair | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Chromosome Maintenance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of the pre-replicative complex | ||||
Base Excision Repair | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Chromosome Maintenance | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA polymerase epsilon 4, accessory subunit | VGNC:10290 | 459343 | |||||
Macaque | DNA polymerase epsilon 4, accessory subunit | 710562 | ||||||
Mouse | MGI:1914229 | 66979 | ||||||
Rat | RGD:1307793 | 362385 | ||||||
Horse | DNA polymerase epsilon 4, accessory subunit | VGNC:21658 | 100068933 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA polymerase epsilon 4, accessory subunit | |||||
Macaque | DNA polymerase epsilon 4, accessory subunit | |||||
Mouse | ||||||
Rat | ||||||
Horse | DNA polymerase epsilon 4, accessory subunit | |||||
Publication Statistics
PubMed Score 4.75
PubMed score by year
PubTator Score 388.95
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (1)
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