Tbio POLE4 DNA polymerase epsilon subunit 4

Protein Summary

Description

May play a role in allowing polymerase epsilon to carry out its replication and/or repair function. POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9NR33
• Q53TR2

Gene Name

• POLE4

Ensembl ID

• ENST00000483063
• ENSP00000420176
• ENSG00000115350

Symbol

• p12
• YHHQ1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
histone modification site profile	0.91
small molecule perturbation	0.77
disease perturbation	0.74
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Dna Polymerase Epsilon Subunit 4

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Dna Polymerase Epsilon Subunit 4

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna-directed Dna Polymerase / Dna Polymerase Epsilon Subunit 4

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Dna Polymerase / Dna Polymerase Epsilon Subunit 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.23   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.23   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0