POLE4
DNA polymerase epsilon subunit 4
Protein Summary
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function. POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
- ENST00000483063
- ENSP00000420176
- ENSG00000115350
- p12
- YHHQ1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
histone modification site profile | 0.91 | ||
small molecule perturbation | 0.77 | ||
disease perturbation | 0.74 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.23 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 72 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.23 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 72 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0