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Tdark
POLE4
DNA polymerase epsilon subunit 4

Protein Summary
Description
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function. POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000483063
  • ENSP00000420176
  • ENSG00000115350

Symbol
  • p12
  • YHHQ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
histone modification site profile
0.91
small molecule perturbation
0.77
disease perturbation
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (222)
POLE
Tclin
Family:  Enzyme
Novelty:  0.00371129
p_int:  0.999988876
p_ni:  0.000011125
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
POLE3
Tbio
Family:  Enzyme
Novelty:  0.09657513
p_int:  0.999931776
p_ni:  0.000066728
p_wrong:  0.000001497
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.999905353
p_ni:  0.000094647
Score:  0.795
Data Source:  BioPlex,STRINGDB
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  0.999899453
p_ni:  0.000096883
p_wrong:  0.000003664
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
YEATS2
Tbio
Novelty:  0.17584498
p_int:  0.999503708
p_ni:  0.000496292
Score:  0.887
Data Source:  BioPlex,STRINGDB
ZZZ3
Tdark
Family:  TF
Novelty:  0.23862921
p_int:  0.999310667
p_ni:  0.000689328
p_wrong:  5e-9
Score:  0.36
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.998478455
p_ni:  0.001521472
p_wrong:  7.3e-8
Score:  0.906
Data Source:  BioPlex,STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.996907913
p_ni:  0.002992399
p_wrong:  0.000099688
Data Source:  BioPlex
LIN7B
Tbio
Novelty:  0.12689192
p_int:  0.968050008
p_ni:  0.022412954
p_wrong:  0.009537038
Data Source:  BioPlex
TADA2A
Tbio
Family:  TF
Novelty:  0.07665459
p_int:  0.967073014
p_ni:  0.007396307
p_wrong:  0.025530679
Score:  0.655
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
POLE
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  3
POLA1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  1
Pathways (39)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase epsilon 4, accessory subunit
VGNC:10290
459343
Macaque
DNA polymerase epsilon 4, accessory subunit
710562
Mouse
MGI:1914229
66979
Rat
RGD:1307793
362385
Horse
DNA polymerase epsilon 4, accessory subunit
VGNC:21658
100068933
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase epsilon 4, accessory subunit
Macaque
DNA polymerase epsilon 4, accessory subunit
Mouse
Rat
Horse
DNA polymerase epsilon 4, accessory subunit
Publication Statistics
PubMed Score 4.75
PubMed score by year
PubTator Score 388.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title