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Tclin
POLE
DNA polymerase epsilon catalytic subunit A

Protein Summary
Description
Participates in DNA repair and in chromosomal DNA replication. This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320574
  • ENSP00000322570
  • ENSG00000177084

Symbol
  • POLE1
  • FILS
  • POLE1
  • CRCS12
  • IMAGEI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
protein domain
0.85
molecular function
0.84
cellular component
0.71
histone modification site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.42   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.42   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (369)
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.999988876
p_ni:  0.000011125
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
POLE3
Tbio
Family:  Enzyme
Novelty:  0.09657513
p_int:  0.999817296
p_ni:  0.000182704
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
C16orf45
Tbio
Novelty:  0.00913059
p_int:  0.979392571
p_ni:  0.020607429
Score:  0.54
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.965418735
p_ni:  0.034581265
Data Source:  BioPlex
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.92978196
p_ni:  0.07021804
Score:  0.2
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.923644536
p_ni:  0.076355464
Data Source:  BioPlex
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.895821095
p_ni:  0.104178905
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.858048401
p_ni:  0.141951599
Data Source:  BioPlex
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.823867632
p_ni:  0.176132368
Score:  0.622
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
76.7
hematocrit
2
2
2
73.4
erythrocyte count
1
1
1
59.9
mathematical ability
1
2
2
55.8
reticulocyte measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
76.7
hematocrit
2
73.4
erythrocyte count
1
59.9
mathematical ability
2
55.8
reticulocyte measurement
1
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1196391
18973
Rat
RGD:1594540
304573
Dog
DNA polymerase epsilon, catalytic subunit
VGNC:44779
486223
Horse
DNA polymerase epsilon, catalytic subunit
VGNC:21656
100061669
Cow
DNA polymerase epsilon, catalytic subunit
VGNC:33118
785457
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
DNA polymerase epsilon, catalytic subunit
Horse
DNA polymerase epsilon, catalytic subunit
Cow
DNA polymerase epsilon, catalytic subunit
Publication Statistics
PubMed Score 308.42
PubMed score by year
PubTator Score 12.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title