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Tclin
POLD1
DNA polymerase delta catalytic subunit

Protein Summary
Description
As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440232
  • ENSP00000406046
  • ENSG00000062822
  • ENST00000599857
  • ENSP00000473052

Symbol
  • POLD
  • CDC2
  • MDPL
  • POLD
  • CRCS10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.96
protein domain
0.92
protein complex
0.83
hub protein
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.89   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.89   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (360)
POLD2
Tbio
Family:  Enzyme
Novelty:  0.05932998
p_int:  0.999749253
p_ni:  0.000250747
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.854283095
p_ni:  0.145716905
Data Source:  BioPlex
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.804374947
p_ni:  0.195625053
Data Source:  BioPlex
POLD3
Tbio
Family:  Enzyme
Novelty:  0.02646621
Score:  0.999
Data Source:  Reactome,STRINGDB
POLE
Tclin
Family:  Enzyme
Novelty:  0.00371129
Score:  0.999
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.998
Data Source:  Reactome,STRINGDB
POLD4
Tdark
Family:  Enzyme
Novelty:  0.21865352
Score:  0.997
Data Source:  Reactome,STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.997
Data Source:  Reactome,STRINGDB
LIG1
Tchem
Family:  Enzyme
Novelty:  0.00326816
Score:  0.996
Data Source:  Reactome,STRINGDB
POLA2
Tbio
Family:  Enzyme
Novelty:  0.07371844
Score:  0.996
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
Cytosolic iron-sulfur cluster assembly
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
Cytosolic iron-sulfur cluster assembly
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
1
1
0
1.4
73
2
1
0
1.4
58.4
response to cisplatin
1
1
1
14.2
platinum measurement
1
1
1
14.2
hematocrit
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
0
1.4
73
0
1.4
58.4
response to cisplatin
1
14.2
platinum measurement
1
14.2
hematocrit
1
12.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transcription factor Spi-B
719262
Mouse
MGI:97741
18971
Rat
RGD:621839
59294
Dog
DNA polymerase delta 1, catalytic subunit
VGNC:44774
610047
Horse
DNA polymerase delta 1, catalytic subunit
VGNC:21651
100052455
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transcription factor Spi-B
Mouse
Rat
Dog
DNA polymerase delta 1, catalytic subunit
Horse
DNA polymerase delta 1, catalytic subunit
Publication Statistics
PubMed Score 211.89
PubMed score by year
PubTator Score 285.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title