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Tchem
POLB
DNA polymerase beta

Protein Summary
Description
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265421
  • ENSP00000265421
  • ENSG00000070501
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.96
biological term
0.86
molecular function
0.81
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 553.23   (req: < 5)
Gene RIFs: 144   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 553.23   (req: >= 5)
Gene RIFs: 144   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (110)
APLF
Tbio
Novelty:  0.01347476
p_int:  1
Score:  0.835
Data Source:  BioPlex,STRINGDB
LIG3
Tbio
Family:  Enzyme
Novelty:  0.00809038
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
TDP1
Tchem
Family:  Enzyme
Novelty:  0.00607344
p_int:  0.999999978
p_ni:  2e-8
p_wrong:  2e-9
Score:  0.831
Data Source:  BioPlex,STRINGDB
XRCC1
Tbio
Novelty:  0.00084203
p_int:  0.999999964
p_ni:  3.6e-8
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
PNKP
Tchem
Family:  Enzyme
Novelty:  0.01038571
p_int:  0.999999609
p_ni:  3.65e-7
p_wrong:  2.6e-8
Score:  0.957
Data Source:  BioPlex,Reactome,STRINGDB
PARP2
Tclin
Family:  Enzyme
Novelty:  0.00545618
p_int:  0.9999918
p_ni:  0.0000082
Score:  0.972
Data Source:  BioPlex,STRINGDB
BCKDHB
Tbio
Family:  Enzyme
Novelty:  0.02234969
p_int:  0.999443319
p_ni:  0.00055668
p_wrong:  1e-9
Score:  0.711
Data Source:  BioPlex,STRINGDB
APTX
Tbio
Novelty:  0.00812241
p_int:  0.998968517
p_ni:  0.000015786
p_wrong:  0.001015697
Score:  0.593
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.997480994
p_ni:  0.002519005
p_wrong:  1e-9
Score:  0.762
Data Source:  BioPlex,STRINGDB
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
p_int:  0.995163097
p_ni:  0.004836599
p_wrong:  3.03e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Reactome
Base Excision Repair
Reactome
DNA Repair
Reactome
Deubiquitination
Name
Explore in Pharos
Explore in Source
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Base Excision Repair
DNA Repair
Deubiquitination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue plasminogen activator measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tissue plasminogen activator measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase beta
VGNC:10220
737210
Mouse
MGI:97740
18970
Rat
RGD:3363
29240
Dog
DNA polymerase beta
VGNC:44773
494001
Cow
DNA polymerase beta
VGNC:33112
614688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase beta
Mouse
Rat
Dog
DNA polymerase beta
Cow
DNA polymerase beta
Publication Statistics
PubMed Score 553.23
PubMed score by year
PubTator Score 820.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title