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Tbio
POLA2
DNA polymerase alpha subunit B

Protein Summary
Description
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265465
  • ENSP00000265465
  • ENSG00000014138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.91
transcription factor perturbation
0.91
pathway
0.71
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0