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Tbio
POGZ
Pogo transposable element with ZNF domain

Protein Summary
Description
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271715
  • ENSP00000271715
  • ENSG00000143442
  • ENST00000368863
  • ENSP00000357856
  • ENST00000392723
  • ENSP00000376484
  • ENST00000409503
  • ENSP00000386836
  • ENST00000491586
  • ENSP00000418408
  • ENST00000531094
  • ENSP00000431259

Symbol
  • KIAA0461
  • SUHW5
  • ZNF280E
  • ZNF635
  • MRD37
  • WHSUS
  • ZNF635
  • ZNF280E
  • ZNF635m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.85
kinase perturbation
0.84
microRNA
0.84
interacting protein
0.83
co-expressed gene
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.39   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.39   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999999936
p_ni:  9e-9
p_wrong:  5.7e-8
Score:  0.844
Data Source:  BioPlex,STRINGDB
ZNF428
Tdark
Novelty:  3.23887218
p_int:  0.999999804
p_ni:  1.29e-7
p_wrong:  6.7e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZNF576
Tdark
Family:  TF
Novelty:  13.18548387
p_int:  0.999999726
p_ni:  2.74e-7
Score:  0.194
Data Source:  BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999996627
p_ni:  0.000003373
Data Source:  BioPlex
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.99997817
p_ni:  0.00002183
Data Source:  BioPlex
LCOR
Tbio
Family:  TF
Novelty:  0.01638762
p_int:  0.999466602
p_ni:  0.000533341
p_wrong:  5.8e-8
Data Source:  BioPlex
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.998806853
p_ni:  0.001193144
p_wrong:  3e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.993430958
p_ni:  0.006569027
p_wrong:  1.6e-8
Data Source:  BioPlex
CD4
Tclin
Novelty:  0.00001217
p_int:  0.992524011
p_ni:  0.007475889
p_wrong:  9.9e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.989440886
p_ni:  0.010559113
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
66.8
apolipoprotein A 1 measurement
1
1
1
45.2
calcium measurement
1
1
1
42.3
lymphocyte count
1
1
1
29
gut microbiome measurement
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
66.8
apolipoprotein A 1 measurement
1
45.2
calcium measurement
1
42.3
lymphocyte count
1
29
gut microbiome measurement
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pogo transposable element derived with ZNF domain
VGNC:1464
747555
Macaque
pogo transposable element derived with ZNF domain
710634
Mouse
MGI:2442117
229584
Rat
RGD:1309980
310658
Dog
pogo transposable element derived with ZNF domain
VGNC:44770
100856450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pogo transposable element derived with ZNF domain
Macaque
pogo transposable element derived with ZNF domain
Mouse
Rat
Dog
pogo transposable element derived with ZNF domain
Publication Statistics
PubMed Score 34.39
PubMed score by year
PubTator Score 8.52
PubTator score by year
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Related Publications
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PMID
Year
Title