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Tbio
POGLUT1
Protein O-glucosyltransferase 1

Protein Summary
Description
Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295588
  • ENSP00000295588
  • ENSG00000163389

Symbol
  • C3orf9
  • CLP46
  • KTELC1
  • MDSRP
  • Rumi
  • CLP46
  • MDSRP
  • C3orf9
  • KTELC1
  • LGMD2Z
  • MDS010
  • hCLP46
  • KDELCL1
  • LGMDR21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
kinase perturbation
0.81
virus perturbation
0.76
transcription factor binding site profile
0.65
transcription factor
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.61   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.992262192
p_ni:  0.007737805
p_wrong:  3e-9
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.991525284
p_ni:  0.008474716
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.991260757
p_ni:  0.00873893
p_wrong:  3.13e-7
Data Source:  BioPlex
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.982946529
p_ni:  0.017049076
p_wrong:  0.000004395
Data Source:  BioPlex
DPEP2
Tbio
Family:  Enzyme
Novelty:  0.14691384
p_int:  0.982088468
p_ni:  0.017911532
Data Source:  BioPlex
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.974344279
p_ni:  0.02565572
p_wrong:  1e-9
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.974034075
p_ni:  0.025965874
p_wrong:  5.1e-8
Data Source:  BioPlex
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
p_int:  0.969693251
p_ni:  0.03030271
p_wrong:  0.000004039
Data Source:  BioPlex
NAAA
Tchem
Family:  Enzyme
Novelty:  0.00368876
p_int:  0.967984797
p_ni:  0.032015197
p_wrong:  6e-9
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.967969991
p_ni:  0.032018673
p_wrong:  0.000011335
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Pre-NOTCH Expression and Processing (R-HSA-1912422)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Pre-NOTCH Expression and Processing
Reactome
Pre-NOTCH Processing in the Endoplasmic Reticulum
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Name
Explore in Pharos
Explore in Source
Pre-NOTCH Expression and Processing
Pre-NOTCH Processing in the Endoplasmic Reticulum
Signal Transduction
Signaling by NOTCH
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
92.6
4
4
0
1.2
84.3
primary biliary cirrhosis
4
3
0
1.4
79.8
2
2
0
1.3
64.3
Thyroid preparation use measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
92.6
0
1.2
84.3
primary biliary cirrhosis
0
1.4
79.8
0
1.3
64.3
Thyroid preparation use measurement
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein O-glucosyltransferase 1
VGNC:2519
460605
Macaque
protein O-glucosyltransferase 1
712357
Mouse
MGI:2444232
224143
Rat
RGD:1306248
288091
Dog
protein O-glucosyltransferase 1
VGNC:44769
487993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein O-glucosyltransferase 1
Macaque
protein O-glucosyltransferase 1
Mouse
Rat
Dog
protein O-glucosyltransferase 1
Publication Statistics
PubMed Score 30.61
PubMed score by year
PubTator Score 37.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title