You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POFUT2
GDP-fucose protein O-fucosyltransferase 2

Protein Summary
Description
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. Fucose is typically found as a terminal modification of branched chain glycoconjugates, but it also exists in direct O-linkage to serine or threonine residues within cystine knot motifs in epidermal growth factor (EGF; MIM 131530)-like repeats or thrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331343
  • ENSP00000329682
  • ENSG00000186866
  • ENST00000334538
  • ENSP00000335427
  • ENST00000349485
  • ENSP00000339613

Symbol
  • C21orf80
  • FUT13
  • KIAA0958
  • FUT13
  • C21orf80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
co-expressed gene
0.82
interacting protein
0.8
transcription factor binding site profile
0.76
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.4   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.4   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.985
Data Source:  STRINGDB
POFUT1
Tbio
Family:  Enzyme
Novelty:  0.0176011
Score:  0.979
Data Source:  STRINGDB
ADAMTSL2
Tbio
Novelty:  0.05511648
Score:  0.973
Data Source:  STRINGDB
ADAMTS13
Tbio
Family:  Enzyme
Novelty:  0.0006095
Score:  0.963
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.962
Data Source:  STRINGDB
ADAMTS17
Tbio
Family:  Enzyme
Novelty:  0.04568792
Score:  0.958
Data Source:  STRINGDB
ADAMTSL4
Tbio
Novelty:  0.03890484
Score:  0.958
Data Source:  STRINGDB
ADAMTS10
Tbio
Family:  Enzyme
Novelty:  0.03532209
Score:  0.956
Data Source:  STRINGDB
THSD4
Tbio
Novelty:  0.12898073
Score:  0.948
Data Source:  STRINGDB
ADAMTSL3
Tbio
Novelty:  0.07699522
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-glycosylation of TSR domain-containing proteins
Reactome
O-linked glycosylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-glycosylation of TSR domain-containing proteins
O-linked glycosylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
4
4
77.1
waist-hip ratio
1
3
3
72.5
waist circumference
1
2
2
51.7
BMI-adjusted waist circumference
1
2
2
49.2
smoking behaviour measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
77.1
waist-hip ratio
3
72.5
waist circumference
2
51.7
BMI-adjusted waist circumference
2
49.2
smoking behaviour measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein O-fucosyltransferase 2
VGNC:1133
449505
Macaque
protein O-fucosyltransferase 2
721991
Mouse
MGI:1916863
80294
Rat
RGD:1307334
309686
Dog
protein O-fucosyltransferase 2
VGNC:49690
100855959
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein O-fucosyltransferase 2
Macaque
protein O-fucosyltransferase 2
Mouse
Rat
Dog
protein O-fucosyltransferase 2
Publication Statistics
PubMed Score 17.40
PubMed score by year
PubTator Score 8.95
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title