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Tbio
POF1B
Protein POF1B

Protein Summary
Description
Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262753
  • ENSP00000262753
  • ENSG00000124429
  • ENST00000373145
  • ENSP00000362238

Symbol
  • POF
  • POF2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
interacting protein
0.74
microRNA
0.65
PubMedID
0.64
gene perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999886511
p_ni:  0.000113489
Data Source:  BioPlex
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.999232344
p_ni:  0.000767656
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.998124795
p_ni:  0.001875205
Data Source:  BioPlex
DTL
Tbio
Novelty:  0.01659105
p_int:  0.997743082
p_ni:  0.002256918
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.994216593
p_ni:  0.005783407
Data Source:  BioPlex
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.993640749
p_ni:  0.006359251
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.993501679
p_ni:  0.006498321
Data Source:  BioPlex
KIR3DS1
Tdark
p_int:  0.99214552
p_ni:  0.00785448
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.991083738
p_ni:  0.008916262
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.984588067
p_ni:  0.015411933
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POF1B, actin binding protein
VGNC:48890
473686
Macaque
POF1B, actin binding protein
694245
Mouse
MGI:1916943
69693
Rat
RGD:1560798
302328
Dog
POF1B, actin binding protein
VGNC:44766
491994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POF1B, actin binding protein
Macaque
POF1B, actin binding protein
Mouse
Rat
Dog
POF1B, actin binding protein
Publication Statistics
PubMed Score 10.17
PubMed score by year
PubTator Score 137.09
PubTator score by year
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Related Publications
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PMID
Year
Title