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Tbio
PODXL2
Podocalyxin-like protein 2

Protein Summary
Description
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins. This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342480
  • ENSP00000345359
  • ENSG00000114631

Symbol
  • EG
  • PODLX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
small molecule perturbation
0.64
histone modification site profile
0.53
PubMedID
0.49
cell line
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.42   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.42   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.999982024
p_ni:  0.000017976
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999953051
p_ni:  0.00004692
p_wrong:  2.9e-8
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.999930337
p_ni:  0.000069613
p_wrong:  5e-8
Data Source:  BioPlex
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.999914959
p_ni:  0.000083999
p_wrong:  0.000001042
Score:  0.22
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.999867317
p_ni:  0.00013261
p_wrong:  7.2e-8
Data Source:  BioPlex
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999833378
p_ni:  0.000166511
p_wrong:  1.1e-7
Score:  0.295
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.999727219
p_ni:  0.000272781
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999664808
p_ni:  0.000333812
p_wrong:  0.000001379
Score:  0.201
Data Source:  BioPlex,STRINGDB
TPBG
Tbio
Novelty:  0.00839213
p_int:  0.999322205
p_ni:  6.4e-8
p_wrong:  0.000677731
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.996096547
p_ni:  0.00312093
p_wrong:  0.000782524
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
52
high density lipoprotein cholesterol measurement
1
1
1
49.5
triglyceride measurement
1
1
1
36.5
refractive error measurement
1
1
1
26.1
BMI-adjusted waist-hip ratio
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
52
high density lipoprotein cholesterol measurement
1
49.5
triglyceride measurement
1
36.5
refractive error measurement
1
26.1
BMI-adjusted waist-hip ratio
1
6.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
podocalyxin like 2
VGNC:7097
471068
Macaque
podocalyxin like 2
710701
Mouse
MGI:2442488
319655
Rat
RGD:1305815
297433
Dog
podocalyxin like 2
VGNC:44765
484623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
podocalyxin like 2
Macaque
podocalyxin like 2
Mouse
Rat
Dog
podocalyxin like 2
Publication Statistics
PubMed Score 8.42
PubMed score by year
PubTator Score 7.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title