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Tbio
POC1B
POC1 centriolar protein homolog B

Protein Summary
Description
Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313546
  • ENSP00000323302
  • ENSG00000139323
  • ENST00000549035
  • ENSP00000447916

Symbol
  • WDR51B
  • PIX1
  • CORD20
  • TUWD12
  • WDR51B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
protein domain
0.73
tissue sample
0.69
transcription factor perturbation
0.68
cellular component
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.27   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.27   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
GALNT4
Tbio
Family:  Enzyme
Novelty:  0.05200323
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.409
Data Source:  BioPlex,STRINGDB
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.822
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.99999988
p_ni:  1.2e-7
Score:  0.813
Data Source:  BioPlex,STRINGDB
ZNF598
Tbio
Novelty:  0.10104457
p_int:  0.999999453
p_ni:  5.47e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
SARM1
Tchem
Novelty:  0.00510488
p_int:  0.99995905
p_ni:  0.000040885
p_wrong:  6.5e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999953908
p_ni:  0.000046091
Score:  0.355
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999907145
p_ni:  0.000092854
p_wrong:  1e-9
Score:  0.162
Data Source:  BioPlex,STRINGDB
TACC1
Tbio
Novelty:  0.03556945
p_int:  0.999672723
p_ni:  0.000296035
p_wrong:  0.000031242
Data Source:  BioPlex
SIL1
Tbio
Novelty:  0.00848561
p_int:  0.999203958
p_ni:  0.000670451
p_wrong:  0.000125591
Score:  0.181
Data Source:  BioPlex,STRINGDB
NELL2
Tbio
Family:  Enzyme
Novelty:  0.03760438
p_int:  0.997797089
p_ni:  0.002196363
p_wrong:  0.000006548
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
4
1.1
92.1
monocyte count
2
2
2
84.7
3
3
3
80.7
systolic blood pressure
1
1
1
76
mean arterial pressure
1
1
1
71.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
92.1
monocyte count
2
84.7
3
80.7
systolic blood pressure
1
76
mean arterial pressure
1
71.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POC1 centriolar protein B
VGNC:13342
100608235
Macaque
POC1 centriolar protein B
709011
Mouse
MGI:1918511
382406
Rat
RGD:2323942
100362836
Dog
POC1 centriolar protein B
VGNC:54220
475422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POC1 centriolar protein B
Macaque
POC1 centriolar protein B
Mouse
Rat
Dog
POC1 centriolar protein B
Publication Statistics
PubMed Score 14.27
PubMed score by year
PubTator Score 6.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title