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Tbio
POC1A
POC1 centriolar protein homolog A

Protein Summary
Description
Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation. POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296484
  • ENSP00000296484
  • ENSG00000164087
  • ENST00000394970
  • ENSP00000378421
  • ENST00000474012
  • ENSP00000418968

Symbol
  • WDR51A
  • PIX2
  • SOFT
  • WDR51A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.83
protein domain
0.73
tissue sample
0.63
transcription factor
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.42   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.42   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
POC1B
Tbio
Novelty:  0.09023863
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.822
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.999999921
p_ni:  7.9e-8
Score:  0.665
Data Source:  BioPlex,STRINGDB
SIL1
Tbio
Novelty:  0.00848561
p_int:  0.999997144
p_ni:  0.000002856
Data Source:  BioPlex
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999984282
p_ni:  0.000015718
Score:  0.184
Data Source:  BioPlex,STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.999984015
p_ni:  0.000015985
Data Source:  BioPlex
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999980822
p_ni:  0.000019178
Data Source:  BioPlex
NELL2
Tbio
Family:  Enzyme
Novelty:  0.03760438
p_int:  0.999882649
p_ni:  0.000117351
Data Source:  BioPlex
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.999877081
p_ni:  0.000122919
Data Source:  BioPlex
IKZF1
Tbio
Family:  TF
Novelty:  0.0016117
p_int:  0.999755722
p_ni:  0.000244278
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.997588015
p_ni:  0.002411984
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
3
4
74
IGF-1 measurement
1
1
1
69.4
worry measurement
2
2
2
6
64.8
waist circumference
1
2
2
59
wellbeing measurement
3
1
3
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
4
74
IGF-1 measurement
1
69.4
worry measurement
2
6
64.8
waist circumference
2
59
wellbeing measurement
3
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POC1 centriolar protein A
VGNC:12126
460415
Macaque
POC1 centriolar protein A
698157
Mouse
MGI:1917485
70235
Rat
RGD:1565004
501048
Dog
POC1 centriolar protein A
484741
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POC1 centriolar protein A
Macaque
POC1 centriolar protein A
Mouse
Rat
Dog
POC1 centriolar protein A
Publication Statistics
PubMed Score 30.42
PubMed score by year
PubTator Score 58.66
PubTator score by year
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Related Publications
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PMID
Year
Title