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Tbio
PNRC1
Proline-rich nuclear receptor coactivator 1

Protein Summary
Description
Nuclear receptor coactivator. May play a role in signal transduction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336032
  • ENSP00000336931
  • ENSG00000146278

Symbol
  • PROL2
  • B4-2
  • PRR2
  • PROL2
  • PNAS-145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
gene perturbation
0.81
small molecule perturbation
0.8
transcription factor
0.75
microRNA
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
p_int:  0.9729392
p_ni:  4.5e-8
p_wrong:  0.027060755
Score:  0.519
Data Source:  BioPlex,STRINGDB
DCP1A
Tbio
Novelty:  0.02038933
Score:  0.764
Data Source:  STRINGDB
DCP1B
Tdark
Novelty:  0.36605365
Score:  0.753
Data Source:  STRINGDB
TMEM35A
Tdark
Novelty:  0.25101021
Score:  0.703
Data Source:  STRINGDB
SSNA1
Tbio
Novelty:  0.02189473
Score:  0.662
Data Source:  STRINGDB
C4BPA
Tbio
Novelty:  0.00319944
Score:  0.648
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.644
Data Source:  STRINGDB
NDUFB9
Tclin
Family:  Enzyme
Novelty:  0.00715628
Score:  0.641
Data Source:  STRINGDB
CRKL
Tbio
Novelty:  0.0051181
Score:  0.622
Data Source:  STRINGDB
TRIM5
Tbio
Novelty:  0.00289445
Score:  0.621
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
1
1
43.7
blood metabolite measurement
1
1
1
30.8
monocyte percentage of leukocytes
1
1
1
10.3
monocyte count
1
1
1
9
sleep duration
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lifestyle measurement
1
43.7
blood metabolite measurement
1
30.8
monocyte percentage of leukocytes
1
10.3
monocyte count
1
9
sleep duration
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline rich nuclear receptor coactivator 1
VGNC:3630
742894
Macaque
proline rich nuclear receptor coactivator 1
700362
Mouse
MGI:1917838
108767
Rat
RGD:628753
286988
Dog
proline rich nuclear receptor coactivator 1
VGNC:44761
100683541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline rich nuclear receptor coactivator 1
Macaque
proline rich nuclear receptor coactivator 1
Mouse
Rat
Dog
proline rich nuclear receptor coactivator 1
Publication Statistics
PubMed Score 173.00
PubMed score by year
PubTator Score 100.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title