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Tchem
PNPO
Pyridoxine-5'-phosphate oxidase

Protein Summary
Description
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225573
  • ENSP00000225573
  • ENSG00000108439
  • ENST00000434554
  • ENSP00000399960
  • ENST00000582171
  • ENSP00000463994
  • ENST00000585320
  • ENSP00000462345
  • ENST00000641856
  • ENSP00000493224
  • ENST00000642017
  • ENSP00000493302

Symbol
  • PDXPO
  • HEL-S-302
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.84
histone modification site profile
0.8
disease perturbation
0.79
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.4   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.4   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (75)
MTERF1
Tbio
Novelty:  0.00983613
p_int:  0.999999998
p_ni:  2e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.999877878
p_ni:  0.000122122
Data Source:  BioPlex
MOK
Tbio
Family:  Kinase
Novelty:  0.0116106
p_int:  0.999247511
p_ni:  0.000537138
p_wrong:  0.00021535
Score:  0.534
Data Source:  BioPlex,STRINGDB
FBXO25
Tbio
Novelty:  0.1205608
p_int:  0.989270973
p_ni:  0.005529442
p_wrong:  0.005199584
Score:  0.534
Data Source:  BioPlex,STRINGDB
ARL6IP6
Tdark
Novelty:  0.36643453
p_int:  0.988615387
p_ni:  0.007537365
p_wrong:  0.003847247
Score:  0.2
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.931878281
p_ni:  0.056639261
p_wrong:  0.011482458
Data Source:  BioPlex
SLC25A32
Tbio
Family:  Transporter
Novelty:  0.06270404
p_int:  0.930177477
p_ni:  0.069818556
p_wrong:  0.000003966
Score:  0.267
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.920965506
p_ni:  0.078973821
p_wrong:  0.000060672
Data Source:  BioPlex
PDXK
Tbio
Family:  Kinase
Novelty:  0.00976418
Score:  0.99
Data Source:  STRINGDB
PHOSPHO2
Tdark
Family:  Enzyme
Novelty:  0.36911271
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamins B6 activation to pyridoxal phosphate
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamins B6 activation to pyridoxal phosphate
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3
0
1.1
93.5
BMI-adjusted hip circumference
2
4
5
77.3
hematocrit
1
1
1
63.4
neutrophil count
2
2
2
46.9
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
93.5
BMI-adjusted hip circumference
5
77.3
hematocrit
1
63.4
neutrophil count
2
46.9
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyridoxamine 5'-phosphate oxidase
VGNC:9532
749248
Macaque
pyridoxamine 5'-phosphate oxidase
694949
Mouse
MGI:2144151
103711
Rat
RGD:621456
64533
Dog
pyridoxamine 5'-phosphate oxidase
VGNC:44759
480540
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyridoxamine 5'-phosphate oxidase
Macaque
pyridoxamine 5'-phosphate oxidase
Mouse
Rat
Dog
pyridoxamine 5'-phosphate oxidase
Publication Statistics
PubMed Score 113.40
PubMed score by year
PubTator Score 61.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title