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Tdark
PNPLA7
Patatin-like phospholipase domain-containing protein 7

Protein Summary
Description
Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).[supplied by OMIM, Jun 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277531
  • ENSP00000277531
  • ENSG00000130653
  • ENST00000406427
  • ENSP00000384610

Symbol
  • C9orf111
  • NTEL1
  • NTE-R1
  • C9orf111
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
transcription factor binding site profile
0.78
protein domain
0.73
cellular component
0.68
transcription factor
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.31   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.31   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0