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Tbio
PNPLA6
Neuropathy target esterase

Protein Summary
Description
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221249
  • ENSP00000221249
  • ENSG00000032444
  • ENST00000414982
  • ENSP00000407509
  • ENST00000450331
  • ENSP00000394348
  • ENST00000545201
  • ENSP00000443323

Symbol
  • NTE
  • NTE
  • sws
  • BNHS
  • LNMS
  • OMCS
  • SPG39
  • NTEMND
  • iPLA2delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
protein domain
0.85
transcription factor
0.8
metabolite
0.78
interacting protein
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.93   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.93   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
IFNLR1
Tbio
Novelty:  0.01990628
p_int:  0.980946792
p_ni:  0.019053208
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.973474803
p_ni:  0.026525197
Data Source:  BioPlex
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.965651363
p_ni:  0.034348637
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.963658886
p_ni:  0.036341114
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.958018845
p_ni:  0.041981155
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.919451525
p_ni:  0.080548475
Data Source:  BioPlex
PCDHB16
Tdark
Novelty:  0.67206411
p_int:  0.907507894
p_ni:  0.092492106
Data Source:  BioPlex
STIM1
Tbio
Novelty:  0.00116516
p_int:  0.892541484
p_ni:  0.107458516
Data Source:  BioPlex
PCDHGC5
Tdark
Novelty:  0.39651826
p_int:  0.885063203
p_ni:  0.114936797
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.876959444
p_ni:  0.123040546
p_wrong:  1e-8
Data Source:  BioPlex
Pathways (6)
Glycerophospholipid catabolism (R-HSA-6814848)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid catabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid catabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
20
58.4
mean platelet volume
1
1
1
53.7
left ventricular structural measurement
3
1
3
49.5
opioid overdose severity measurement
1
1
1
31.4
neuropathic pain
1
1
0
1.7
7.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
20
58.4
mean platelet volume
1
53.7
left ventricular structural measurement
3
49.5
opioid overdose severity measurement
1
31.4
neuropathic pain
0
1.7
7.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 6
VGNC:6648
455659
Macaque
patatin like phospholipase domain containing 6
100426338
Mouse
MGI:1354723
50767
Rat
RGD:1564611
360753
Dog
patatin like phospholipase domain containing 6
VGNC:44756
484993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 6
Macaque
patatin like phospholipase domain containing 6
Mouse
Rat
Dog
patatin like phospholipase domain containing 6
Publication Statistics
PubMed Score 341.93
PubMed score by year
PubTator Score 299.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title