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Tbio
PNPLA4
Patatin-like phospholipase domain-containing protein 4

Protein Summary
Description
Lipid hydrolase. This gene encodes a member of the patatin-like family of phospholipases. The encoded enzyme has both triacylglycerol lipase and transacylase activities and may be involved in adipocyte triglyceride homeostasis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome Y. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381042
  • ENSP00000370430
  • ENSG00000006757
  • ENST00000444736
  • ENSP00000415245
  • ENST00000537427
  • ENSP00000443157

Symbol
  • DXS1283E
  • GS2
  • GS2
  • DXS1283E
  • iPLA2eta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
virus perturbation
0.79
tissue sample
0.67
histone modification site profile
0.66
PubMedID
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.997675025
p_ni:  0.002324975
Score:  0.259
Data Source:  BioPlex,STRINGDB
SNX11
Tbio
Novelty:  0.21586113
p_int:  0.894500489
p_ni:  0.105480035
p_wrong:  0.000019476
Score:  0.221
Data Source:  BioPlex,STRINGDB
TIGAR
Tbio
Family:  Enzyme
Novelty:  0.0090389
p_int:  0.756297969
p_ni:  0.157367165
p_wrong:  0.086334865
Score:  0.496
Data Source:  BioPlex,STRINGDB
LIPE
Tchem
Family:  Enzyme
Novelty:  0.00169872
Score:  0.972
Data Source:  STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
Score:  0.919
Data Source:  STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.909
Data Source:  STRINGDB
ADH7
Tchem
Family:  Enzyme
Novelty:  0.00488034
Score:  0.909
Data Source:  STRINGDB
DHRS3
Tbio
Family:  Enzyme
Novelty:  0.04448013
Score:  0.901
Data Source:  STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.901
Data Source:  STRINGDB
SDR16C5
Tbio
Family:  Enzyme
Novelty:  0.11319496
Score:  0.901
Data Source:  STRINGDB
Pathways (6)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride catabolism
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride catabolism
Triglyceride metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
21.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 4
VGNC:12542
473881
Macaque
patatin like phospholipase domain containing 4
708139
Rat
RGD:1562200
363471
Dog
patatin like phospholipase domain containing 4
VGNC:54182
491729
Horse
patatin like phospholipase domain containing 4
VGNC:21634
100050789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 4
Macaque
patatin like phospholipase domain containing 4
Rat
Dog
patatin like phospholipase domain containing 4
Horse
patatin like phospholipase domain containing 4
Publication Statistics
PubMed Score 13.47
PubMed score by year
PubTator Score 53.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title