Tbio PNPLA3 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

Protein Summary

Description

Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NST1
• B0QYI0
• B2RCL3
• B3KW00
• Q6P1A1
• Q96CB4

Gene Name

• PNPLA3

Ensembl ID

• ENST00000216180
• ENSP00000216180
• ENSG00000100344
• ENST00000423180
• ENSP00000397987

Symbol

• ADPN
• C22orf20
• ADPN
• C22orf20
• iPLA(2)epsilon

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
phenotype	0.91
biological term	0.85
histone modification site profile	0.75
trait	0.75

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3

Protein / Hydrolase / Lipase / Phospholipase / 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Patatin-like Phospholipase Domain-containing Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 813.16   (req: < 5)

Gene RIFs: 401   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 813.16   (req: >= 5)

Gene RIFs: 401   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0