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Tchem
PNPLA2
Patatin-like phospholipase domain-containing protein 2

Protein Summary
Description
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336615
  • ENSP00000337701
  • ENSG00000177666

Symbol
  • ATGL
  • ATGL
  • TTS2
  • PEDF-R
  • FP17548
  • TTS-2.2
  • iPLA2zeta
  • 1110001C14Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
metabolite
0.88
transcription factor perturbation
0.88
transcription factor
0.69
disease
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.51   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 486   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.51   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 486   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (271)
G0S2
Tbio
Novelty:  0.02273959
p_int:  0.999999539
p_ni:  4.61e-7
Score:  0.901
Data Source:  BioPlex,STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.998621848
p_ni:  0.000001988
p_wrong:  0.001376164
Score:  0.606
Data Source:  BioPlex,STRINGDB
PEX14
Tbio
Novelty:  0.0210557
p_int:  0.908848327
p_ni:  0.09115166
p_wrong:  1.3e-8
Score:  0.208
Data Source:  BioPlex,STRINGDB
TXNRD2
Tbio
Family:  Enzyme
Novelty:  0.002052
p_int:  0.859327101
p_ni:  0.140670465
p_wrong:  0.000002434
Score:  0.263
Data Source:  BioPlex,STRINGDB
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.763755781
p_ni:  0.236244068
p_wrong:  1.51e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
Score:  0.996
Data Source:  STRINGDB
LIPE
Tchem
Family:  Enzyme
Novelty:  0.00169872
Score:  0.996
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.975
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.969
Data Source:  STRINGDB
LIPC
Tchem
Family:  Enzyme
Novelty:  0.00219107
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 4 of 4
INSR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
PNLIP
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
LIPF
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
DGAT1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (128)
Acyl chain remodeling of DAG and TAG (R-HSA-1482883)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of DAG and TAG
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of DAG and TAG
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
6.6
94.3
intraocular pressure measurement
2
3
3
94.1
BMI-adjusted waist-hip ratio
5
6
13
91.4
corneal resistance factor
2
1
2
85
mean platelet volume
2
2
2
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
6.6
94.3
intraocular pressure measurement
3
94.1
BMI-adjusted waist-hip ratio
13
91.4
corneal resistance factor
2
85
mean platelet volume
2
79.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 2
VGNC:6540
450937
Mouse
MGI:1914103
66853
Rat
RGD:1309044
361676
Dog
patatin like phospholipase domain containing 2
VGNC:44753
611403
Cow
patatin like phospholipase domain containing 2
VGNC:33091
508493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patatin like phospholipase domain containing 2
Mouse
Rat
Dog
patatin like phospholipase domain containing 2
Cow
patatin like phospholipase domain containing 2
Publication Statistics
PubMed Score 816.51
PubMed score by year
PubTator Score 292.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title