Tbio PNOC Prepronociceptin

Protein Summary

Description

Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. Orphanin FQ2: Has potent analgesic activity. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q13519
• B7Z749
• Q6FH16

Gene Name

• PNOC

Ensembl ID

• ENST00000301908
• ENSP00000301908
• ENSG00000168081
• ENST00000522209
• ENSP00000430145

Symbol

• OFQ
• NOP
• OFQ
• N/OFQ
• PPNOC
• ppN/OFQ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.83
disease	0.52
PubMedID	0.51
chemical	0.5
pathway	0.47

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Neuropeptide / Prepronociceptin

DTO Classes

Protein / Signaling / Hormone / Neuropeptide / Prepronociceptin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 937.72   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 937.72   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0