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Tbio
PNO1
RNA-binding protein PNO1

Protein Summary
Description
Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263657
  • ENSP00000263657
  • ENSG00000115946

Symbol
  • RRP20
  • KHRBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
protein complex
0.92
histone modification site profile
0.9
transcription factor perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (349)
UTP14C
Tdark
Novelty:  0.22698737
p_int:  0.999998147
p_ni:  0.00000181
p_wrong:  4.3e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
NOB1
Tbio
Novelty:  0.01209681
p_int:  0.999986493
p_ni:  0.000013507
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.998744347
p_ni:  0.001255652
p_wrong:  1e-9
Data Source:  BioPlex
UTP14A
Tbio
Novelty:  0.06076507
p_int:  0.997527141
p_ni:  0.002472859
Score:  0.997
Data Source:  BioPlex,STRINGDB
MTMR3
Tbio
Family:  Enzyme
Novelty:  0.04961778
p_int:  0.996974484
p_ni:  0.003025516
Score:  0.252
Data Source:  BioPlex,STRINGDB
RCL1
Tbio
Family:  Enzyme
Novelty:  0.02116964
Score:  0.999
Data Source:  STRINGDB
WDR3
Tbio
Novelty:  0.15410886
Score:  0.999
Data Source:  STRINGDB
KRR1
Tbio
Novelty:  0.07965454
Score:  0.999
Data Source:  STRINGDB
DCAF13
Tbio
Novelty:  0.02796363
Score:  0.999
Data Source:  STRINGDB
BYSL
Tbio
Novelty:  0.01919968
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
3
2
5.8
50.5
lifestyle measurement
1
1
1
37.6
Varicose veins
1
1
1
33
potassium measurement
1
1
1
28.1
diastolic blood pressure change measurement
1
1
0
12
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
5.8
50.5
lifestyle measurement
1
37.6
Varicose veins
1
33
potassium measurement
1
28.1
diastolic blood pressure change measurement
0
12
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
partner of NOB1 homolog
VGNC:339
100613305
Macaque
partner of NOB1 homolog
100337566
Mouse
MGI:1913499
66249
Rat
RGD:727882
289809
Dog
partner of NOB1 homolog
VGNC:44749
474623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
partner of NOB1 homolog
Macaque
partner of NOB1 homolog
Mouse
Rat
Dog
partner of NOB1 homolog
Publication Statistics
PubMed Score 21.25
PubMed score by year
PubTator Score 6.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title