Tchem PNMT Phenylethanolamine N-methyltransferase

Protein Summary

Description

Converts noradrenaline to adrenaline. The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• P11086
• PNMTase

Gene Name

• PNMT

Ensembl ID

• ENST00000269582
• ENSP00000269582
• ENSG00000141744

Symbol

• PENT
• PENT
• PNMTase

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.76
virus perturbation	0.76
drug	0.7
cell type or tissue	0.69
disease	0.64

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Phenylethanolamine N-methyltransferase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Phenylethanolamine N-methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.29   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 423   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.29   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0