Tdark PNMA8A Paraneoplastic antigen-like protein 8A

Protein Summary

Uniprot Accession IDs

• Q86V59
• A8K2F3
• Q5U638
• Q8N3H4
• Q9NVE8

Gene Name

• PNMA8A

Ensembl ID

• ENST00000313683
• ENSP00000318131
• ENSG00000182013
• ENST00000438932
• ENSP00000410273

Symbol

• PNMAL1
• PNMAL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.97   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.97   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (46)

Explore Interacting Targets

1 – 10 of 46

• See Interactions on String-DB

RARG

Tclin

Family:  NR

Novelty:  0.00667159

p_int:  0.999999924

p_ni:  6.1e-8

p_wrong:  1.6e-8

Score:  0.269

Data Source:  BioPlex,STRINGDB

PNMA1

Tbio

Novelty:  0.06899807

p_int:  0.999997546

p_ni:  0.000002427

p_wrong:  2.6e-8

Score:  0.847

Data Source:  BioPlex,STRINGDB

MOAP1

Tbio

Novelty:  0.05070263

p_int:  0.999993487

p_ni:  0.000006421

p_wrong:  9.2e-8

Score:  0.863

Data Source:  BioPlex,STRINGDB

CES2

Tchem

Family:  Enzyme

Novelty:  0.00177726

p_int:  0.998756423

p_ni:  0.001243566

p_wrong:  1.1e-8

Data Source:  BioPlex

POLE3

Tbio

Family:  Enzyme

Novelty:  0.09657513

p_int:  0.997753729

p_ni:  0.002246234

p_wrong:  3.6e-8

Data Source:  BioPlex

RTL9

Tbio

Novelty:  0.15059774

Score:  0.769

Data Source:  STRINGDB

RTL5

Tdark

Novelty:  0.07868053

Score:  0.73

Data Source:  STRINGDB

RTL3

Tdark

Novelty:  0.27058386

Score:  0.712

Data Source:  STRINGDB

RTL6

Tbio

Novelty:  0.12824182

Score:  0.703

Data Source:  STRINGDB

ZCCHC12

Tbio

Novelty:  0.16283891

Score:  0.687

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Oral ulcer	HP_0000155	1	2	0	1.1	88
triglyceride measurement	EFO_0004530	1	1	1		59.6
reticulocyte count	EFO_0007986	1	1	1		55.2
hemoglobin measurement	EFO_0004509	2	1	2		53.3
eosinophil count	EFO_0004842	1	1	1		44.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Oral ulcer	HP_0000155	0	1.1	88
triglyceride measurement	EFO_0004530	1		59.6
reticulocyte count	EFO_0007986	1		55.2
hemoglobin measurement	EFO_0004509	2		53.3
eosinophil count	EFO_0004842	1		44.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
basophil percentage of leukocytes
C-reactive protein measurement
eosinophil count
hemoglobin measurement
Oral ulcer
P wave terminal force measurement
reticulocyte count
triglyceride measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	PNMA family member 8A	VGNC:48989	468928
Macaque	PNMA family member 8A		716385
Mouse	PNMA-like 1	MGI:1918941	71691
Rat	PNMA family member 8A	RGD:1310803	361515
Dog	PNMA family member 8A [Source:HGNC Symbol;Acc:HGNC:25578]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	PNMA family member 8A
Macaque	PNMA family member 8A
Mouse	PNMA-like 1
Rat	PNMA family member 8A
Dog	PNMA family member 8A [Source:HGNC Symbol;Acc:HGNC:25578]

Publication Statistics

PubMed Score 0.97

PubMed score by year

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Related Publications

Text Mined References (9)

Items per page:

10

0 of 0

PMID	Year	Title