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Tbio
PNMA1
Paraneoplastic antigen Ma1

Protein Summary
Description
This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316836
  • ENSP00000318914
  • ENSG00000176903

Symbol
  • MA1
  • MA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
kinase perturbation
0.81
cellular component
0.66
cell line
0.61
transcription factor binding site profile
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
MOAP1
Tbio
Novelty:  0.05070263
p_int:  0.999999542
p_ni:  4.27e-7
p_wrong:  3.1e-8
Score:  0.717
Data Source:  BioPlex,STRINGDB
PNMA8A
Tdark
Novelty:  0.95674878
p_int:  0.999997546
p_ni:  0.000002427
p_wrong:  2.6e-8
Score:  0.847
Data Source:  BioPlex,STRINGDB
REPS1
Tbio
Novelty:  0.08952347
p_int:  0.999941578
p_ni:  0.000051123
p_wrong:  0.000007299
Score:  0.183
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.999904417
p_ni:  0.000009621
p_wrong:  0.000085961
Data Source:  BioPlex
ZCCHC12
Tbio
Novelty:  0.16283891
p_int:  0.999458421
p_ni:  8.5e-8
p_wrong:  0.000541494
Score:  0.533
Data Source:  BioPlex,STRINGDB
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.997904903
p_ni:  0.00209347
p_wrong:  0.000001627
Score:  0.19
Data Source:  BioPlex,STRINGDB
UBA5
Tbio
Novelty:  0.05089296
p_int:  0.980282461
p_ni:  0.019717539
Score:  0.173
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.978577338
p_ni:  0.021422662
Score:  0.226
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.941786214
p_ni:  0.058213786
Data Source:  BioPlex
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.844496275
p_ni:  0.155503725
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
4
9
97.6
reticulocyte measurement
3
3
5
96.8
apolipoprotein A 1 measurement
2
2
2
86.6
high density lipoprotein cholesterol measurement
5
2
5
86.6
mean corpuscular hemoglobin concentration
1
1
1
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
97.6
reticulocyte measurement
5
96.8
apolipoprotein A 1 measurement
2
86.6
high density lipoprotein cholesterol measurement
5
86.6
mean corpuscular hemoglobin concentration
1
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PNMA family member 1
VGNC:3357
100611868
Macaque
PNMA family member 1
697618
Mouse
MGI:2180564
70481
Rat
RGD:621230
170636
Dog
PNMA family member 1
VGNC:51671
490774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PNMA family member 1
Macaque
PNMA family member 1
Mouse
Rat
Dog
PNMA family member 1
Publication Statistics
PubMed Score 15.88
PubMed score by year
PubTator Score 81.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title