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Tbio
PMS1
PMS1 protein homolog 1

Protein Summary
Description
Probably involved in the repair of mismatches in DNA. This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409593
  • ENSP00000387169
  • ENSG00000064933
  • ENST00000409823
  • ENSP00000387125
  • ENST00000441310
  • ENSP00000406490
  • ENST00000447232
  • ENSP00000401064

Symbol
  • PMSL1
  • MLH2
  • PMSL1
  • hPMS1
  • HNPCC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
histone modification site profile
0.89
transcription factor binding site profile
0.72
hub protein
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.28   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.28   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
MLH1
Tbio
Novelty:  0.00034212
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.969
Data Source:  BioPlex,STRINGDB
HIST1H1D
Tbio
Novelty:  0.00922175
p_int:  0.999415776
p_ni:  0.000584222
p_wrong:  1e-9
Score:  0.645
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.997220403
p_ni:  0.002779597
Score:  0.15
Data Source:  BioPlex,STRINGDB
SNX21
Tdark
Novelty:  0.32916633
p_int:  0.995248217
p_ni:  0.001610794
p_wrong:  0.00314099
Score:  0.158
Data Source:  BioPlex,STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.973019682
p_ni:  0.026956692
p_wrong:  0.000023626
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.972412053
p_ni:  0.027586923
p_wrong:  0.000001025
Data Source:  BioPlex
PAG1
Tbio
Novelty:  0.01390911
p_int:  0.941155474
p_ni:  0.058831036
p_wrong:  0.00001349
Data Source:  BioPlex
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.917121143
p_ni:  0.082878857
Score:  0.177
Data Source:  BioPlex,STRINGDB
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.913787632
p_ni:  0.085882605
p_wrong:  0.000329763
Data Source:  BioPlex
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.842062876
p_ni:  0.155351682
p_wrong:  0.002585442
Score:  0.428
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PMS1 homolog 1, mismatch repair system component
VGNC:2786
459827
Macaque
PMS1 homolog 1, mismatch repair system component
713641
Mouse
MGI:1202302
227099
Rat
RGD:1359511
494322
Dog
PMS1 homolog 1, mismatch repair system component
VGNC:44738
478840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PMS1 homolog 1, mismatch repair system component
Macaque
PMS1 homolog 1, mismatch repair system component
Mouse
Rat
Dog
PMS1 homolog 1, mismatch repair system component
Publication Statistics
PubMed Score 187.28
PubMed score by year
PubTator Score 96.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title