You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PMPCB
Mitochondrial-processing peptidase subunit beta

Protein Summary
Description
Catalytic subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins (PubMed:29576218). Most MPP cleavage sites follow an arginine at position -2 (By similarity). This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249269
  • ENSP00000249269
  • ENSG00000105819

Symbol
  • MPPB
  • MPPB
  • P-52
  • MPP11
  • MPPP52
  • Beta-MPP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
transcription factor binding site profile
0.81
protein domain
0.73
histone modification site profile
0.69
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.99   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.99   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
PPP4R1
Tbio
Family:  Enzyme
Novelty:  0.10822249
p_int:  0.999997116
p_ni:  0.000002883
Score:  0.26
Data Source:  BioPlex,STRINGDB
PPP4R3A
Tbio
Family:  Enzyme
Novelty:  0.04234592
p_int:  0.999810571
p_ni:  0.000189429
Score:  0.328
Data Source:  BioPlex,STRINGDB
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.998630973
p_ni:  0.001369027
Data Source:  BioPlex
PMPCA
Tbio
Family:  Enzyme
Novelty:  0.01842996
p_int:  0.997832353
p_ni:  0.002167647
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PPP4R3B
Tbio
Family:  Enzyme
Novelty:  0.0185504
p_int:  0.995561499
p_ni:  0.004438496
p_wrong:  6e-9
Score:  0.527
Data Source:  BioPlex,STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.985525478
p_ni:  0.014474522
Score:  0.288
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.972336617
p_ni:  0.027663383
Data Source:  BioPlex
MRM3
Tbio
Family:  Enzyme
Novelty:  0.06515109
p_int:  0.93771355
p_ni:  0.06228645
Score:  0.256
Data Source:  BioPlex,STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.914080604
p_ni:  0.085919396
Data Source:  BioPlex
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.87632388
p_ni:  0.12367612
Score:  0.518
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Mitochondrial protein import
Reactome
Processing of SMDT1
Reactome
Protein localization
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Mitochondrial protein import
Processing of SMDT1
Protein localization
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
74.3
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
74.3
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidase, mitochondrial processing beta subunit
VGNC:8734
463631
Macaque
peptidase, mitochondrial processing beta subunit
695711
Mouse
MGI:1920328
73078
Rat
RGD:621297
64198
Dog
peptidase, mitochondrial processing beta subunit
VGNC:44737
475897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidase, mitochondrial processing beta subunit
Macaque
peptidase, mitochondrial processing beta subunit
Mouse
Rat
Dog
peptidase, mitochondrial processing beta subunit
Publication Statistics
PubMed Score 39.99
PubMed score by year
PubTator Score 12.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title