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Tbio
PMPCA
Mitochondrial-processing peptidase subunit alpha

Protein Summary
Description
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which is required for maturation of the majority of mitochondrial precursor proteins (PubMed:25808372). Most MPP cleavage sites follow an arginine at position -2 (By similarity). The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371717
  • ENSP00000360782
  • ENSG00000165688
  • ENST00000399219
  • ENSP00000416702

Symbol
  • INPP5E
  • KIAA0123
  • MPPA
  • CLA1
  • CPD3
  • P-55
  • SCAR2
  • INPP5E
  • Alpha-MPP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
disease perturbation
0.79
histone modification site profile
0.73
protein domain
0.73
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (130)
NUDT8
Tdark
Novelty:  0.76306116
p_int:  0.999980787
p_ni:  0.000004316
p_wrong:  0.000014897
Score:  0.91
Data Source:  BioPlex,STRINGDB
HLTF
Tbio
Family:  Enzyme
Novelty:  0.01177896
p_int:  0.999899818
p_ni:  0.000100182
Score:  0.244
Data Source:  BioPlex,STRINGDB
RPUSD2
Tdark
Family:  Enzyme
Novelty:  1.41606982
p_int:  0.999666927
p_ni:  0.000250225
p_wrong:  0.000082848
Score:  0.237
Data Source:  BioPlex,STRINGDB
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.998158063
p_ni:  0.001841937
Score:  0.179
Data Source:  BioPlex,STRINGDB
PMPCB
Tbio
Family:  Enzyme
Novelty:  0.0244013
p_int:  0.997832353
p_ni:  0.002167647
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.990663945
p_ni:  0.009336055
Score:  0.196
Data Source:  BioPlex,STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.972133673
p_ni:  0.027866327
Score:  0.377
Data Source:  BioPlex,STRINGDB
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.967617434
p_ni:  0.03238256
p_wrong:  5e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
MRM3
Tbio
Family:  Enzyme
Novelty:  0.06515109
p_int:  0.961442808
p_ni:  0.038557192
Score:  0.569
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.9422459
p_ni:  0.0577541
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Mitochondrial protein import
Reactome
Processing of SMDT1
Reactome
Protein localization
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Mitochondrial protein import
Processing of SMDT1
Protein localization
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
10
4
1.1
98.8
3
4
1
1.2
96.3
HbA1c measurement
3
3
3
94.5
2
2
0
1.2
93.4
4
4
1
1.1
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98.8
1
1.2
96.3
HbA1c measurement
3
94.5
0
1.2
93.4
1
1.1
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidase, mitochondrial processing alpha subunit
VGNC:9188
464862
Macaque
peptidase, mitochondrial processing alpha subunit
721742
Mouse
MGI:1918568
66865
Rat
RGD:727897
296588
Dog
peptidase, mitochondrial processing alpha subunit
VGNC:44736
480677
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidase, mitochondrial processing alpha subunit
Macaque
peptidase, mitochondrial processing alpha subunit
Mouse
Rat
Dog
peptidase, mitochondrial processing alpha subunit
Publication Statistics
PubMed Score 54.31
PubMed score by year
PubTator Score 6.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title