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Tbio
PMP2
Myelin P2 protein

Protein Summary
Description
May play a role in lipid transport protein in Schwann cells. May bind cholesterol. The protein encoded by this gene localizes to myelin sheaths of the peripheral nervous system. The encoded protein can bind both the membrane layers of the sheaths and monomeric lipids, and is thought to provide stability to the sheath. A defect in this gene was shown to be a cause of dominant demyelinating CMT neuropathy. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256103
  • ENSP00000256103
  • ENSG00000147588

Symbol
  • P2
  • MP2
  • CMT1G
  • FABP8
  • M-FABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
gene perturbation
0.63
cell line
0.61
molecular function
0.6
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.81   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.81   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
MAP9
Tbio
Novelty:  0.08883282
Score:  0.908
Data Source:  STRINGDB
GDAP1
Tbio
Novelty:  0.00682376
Score:  0.907
Data Source:  STRINGDB
HINT1
Tchem
Novelty:  0.00815168
Score:  0.879
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.878
Data Source:  STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
Score:  0.866
Data Source:  STRINGDB
DSTN
Tbio
Novelty:  0.0130214
Score:  0.748
Data Source:  STRINGDB
PEX19
Tbio
Novelty:  0.00605342
Score:  0.745
Data Source:  STRINGDB
PRX
Tbio
Novelty:  0.01867283
Score:  0.722
Data Source:  STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
Score:  0.699
Data Source:  STRINGDB
MN1
Tbio
Novelty:  0.0015395
Score:  0.665
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peripheral myelin protein 2
701125
Mouse
MGI:102667
18857
Rat
RGD:1585218
688790
Horse
myelin P2 protein
100050470
Cow
peripheral myelin protein 2
VGNC:53876
506062
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peripheral myelin protein 2
Mouse
Rat
Horse
myelin P2 protein
Cow
peripheral myelin protein 2
Publication Statistics
PubMed Score 233.81
PubMed score by year
PubTator Score 26.37
PubTator score by year
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Related Publications
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PMID
Year
Title