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Tbio
PML
Protein PML

Protein Summary
Description
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, reg ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268058
  • ENSP00000268058
  • ENSG00000140464
  • ENST00000268059
  • ENSP00000268059
  • ENST00000354026
  • ENSP00000315434
  • ENST00000359928
  • ENSP00000353004
  • ENST00000395132
  • ENSP00000378564
  • ENST00000395135
  • ENSP00000378567
  • ENST00000435786
  • ENSP00000395576
  • ENST00000436891
  • ENSP00000394642
  • ENST00000564428
  • ENSP00000457023
  • ENST00000565898
  • ENSP00000455838
  • ENST00000567543
  • ENSP00000456277
  • ENST00000569477
  • ENSP00000455612
  • ENST00000569965
  • ENSP00000456486

Symbol
  • MYL
  • PP8675
  • RNF71
  • TRIM19
  • MYL
  • RNF71
  • PP8675
  • TRIM19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
virus perturbation
1
transcription factor perturbation
0.96
drug perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.3   (req: < 5)
Gene RIFs: 330   (req: <= 3)
Antibodies: 545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.3   (req: >= 5)
Gene RIFs: 330   (req: > 3)
Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0