Protein Summary
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, reg ...more
- ENST00000268058
- ENSP00000268058
- ENSG00000140464
- ENST00000268059
- ENSP00000268059
- ENST00000354026
- ENSP00000315434
- ENST00000359928
- ENSP00000353004
- ENST00000395132
- ENSP00000378564
- ENST00000395135
- ENSP00000378567
- ENST00000435786
- ENSP00000395576
- ENST00000436891
- ENSP00000394642
- ENST00000564428
- ENSP00000457023
- ENST00000565898
- ENSP00000455838
- ENST00000567543
- ENSP00000456277
- ENST00000569477
- ENSP00000455612
- ENST00000569965
- ENSP00000456486
- MYL
- PP8675
- RNF71
- TRIM19
- MYL
- RNF71
- PP8675
- TRIM19
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.96 | ||
drug perturbation | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 283.8 (req: < 5)
Gene RIFs: 330 (req: <= 3)
Antibodies: 545 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 283.8 (req: >= 5)
Gene RIFs: 330 (req: > 3)
Antibodies: 545 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 72
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (401)
ACOT8
Family: Enzyme
Novelty: 0.02218214
p_int: 0.999972054
p_ni: 0.000027946
Score: 0.519
Data Source: BioPlex,STRINGDB
SNX11
Novelty: 0.21586113
p_int: 0.998194592
p_ni: 0.001805408
Score: 0.193
Data Source: BioPlex,STRINGDB
NDUFS1
Family: Enzyme
Novelty: 0.0215624
p_int: 0.989181776
p_ni: 0.010818224
Score: 0.176
Data Source: BioPlex,STRINGDB
TRIML2
Family: Enzyme
Novelty: 0.38455379
p_int: 0.982996873
p_ni: 0.017003127
Score: 0.365
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (48)
Reactome (25)
KEGG (7)
PathwayCommons (9)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (84)
Functions (10)
Components (12)
Processes (62)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
4 | 4 | 0 | 15 | 98.7 | |||||
body height | 4 | 3 | 4 | 92.5 | |||||
appendicular lean mass | 4 | 2 | 4 | 91.7 | |||||
BMI-adjusted waist circumference | 7 | 8 | 23 | 89 | |||||
BMI-adjusted hip circumference | 2 | 9 | 11 | 85.6 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 15 | 98.7 | |||||
body height | 4 | 92.5 | |||||
appendicular lean mass | 4 | 91.7 | |||||
BMI-adjusted waist circumference | 23 | 89 | |||||
BMI-adjusted hip circumference | 11 | 85.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | promyelocytic leukemia | 453736 | ||||||
Macaque | promyelocytic leukemia | 700379 | ||||||
Mouse | MGI:104662 | 18854 | ||||||
Rat | RGD:1562602 | 315713 | ||||||
Dog | promyelocytic leukemia | 487641 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | promyelocytic leukemia | |||||
Macaque | promyelocytic leukemia | |||||
Mouse | ||||||
Rat | ||||||
Dog | promyelocytic leukemia | |||||
Publication Statistics
PubMed Score 283.80
PubMed score by year
PubTator Score 1594.29
PubTator score by year
Related Publications
Text Mined References (440)
GeneRif Annotations (330)
Items per page:
0 of 0
PMID | Year | Title |
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