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Tbio
PMF1
Polyamine-modulated factor 1

Protein Summary
Description
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT. This locus represents naturally occurring read-through transcription between the neighboring PMF1 (polyamine-modulated factor 1) and BGLAP (bone gamma-carboxyglutamate Gla protein) genes on chromosome 1. Alternative splicing results in multiple transcript variants encoding isoforms that share sequence identity with the upstream gene product, but they contain distinct C-termini due to frameshifts versus the downstream gene coding sequence. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368273
  • ENSP00000357256
  • ENSG00000160783
  • ENST00000368277
  • ENSP00000357260
  • ENST00000368279
  • ENSP00000357262

Symbol
  • PMF1
  • PMF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.82
transcription factor binding site profile
0.82
histone modification site profile
0.75
disease perturbation
0.74
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.47   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
NSL1
Tbio
Novelty:  0.01396984
p_int:  1
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
DSN1
Tbio
Novelty:  0.05336903
p_int:  1
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
KIF21B
Tbio
Novelty:  0.06463481
p_int:  1
Data Source:  BioPlex
SPC25
Tbio
Novelty:  0.26354244
p_int:  1
Data Source:  BioPlex,Reactome
SPC24
Tbio
Novelty:  0.03166479
p_int:  0.999999927
p_ni:  7.3e-8
Score:  0.458
Data Source:  BioPlex,Reactome,STRINGDB
BICD2
Tbio
Novelty:  0.01725046
p_int:  0.99999989
p_ni:  1.1e-7
Data Source:  BioPlex
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.999999802
p_ni:  1.98e-7
Score:  0.804
Data Source:  BioPlex,STRINGDB
RUFY2
Tbio
Novelty:  0.50188929
p_int:  0.999999604
p_ni:  3.07e-7
p_wrong:  8.9e-8
Data Source:  BioPlex
GCC2
Tbio
Novelty:  0.03809539
p_int:  0.999999371
p_ni:  6.29e-7
Data Source:  BioPlex
MIS12
Tbio
Novelty:  0.05345698
p_int:  0.99999881
p_ni:  0.000001187
p_wrong:  3e-9
Score:  0.943
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
94.7
HbA1c measurement
4
4
4
90.9
mean corpuscular volume
2
2
2
90.1
serum urea measurement
1
2
2
75.4
red blood cell distribution width
1
2
2
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
94.7
HbA1c measurement
4
90.9
mean corpuscular volume
2
90.1
serum urea measurement
2
75.4
red blood cell distribution width
2
74.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914287
67037
Rat
RGD:1584694
681050
Horse
polyamine-modulated factor 1
100146589
Cow
polyamine modulated factor 1
616311
Pig
polyamine modulated factor 1
100144449
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
polyamine-modulated factor 1
Cow
polyamine modulated factor 1
Pig
polyamine modulated factor 1
Publication Statistics
PubMed Score 19.47
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title