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Tbio
PMCH
Pro-MCH

Protein Summary
Description
MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329406
  • ENSP00000332225
  • ENSG00000183395

Symbol
  • MCH
  • MCH
  • ppMCH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
gene perturbation
0.53
pathway
0.52
small molecule perturbation
0.52
tissue sample
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.83   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.83   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (404)
MIB2
Tbio
Family:  Enzyme
Novelty:  0.044378
p_int:  0.999999989
p_ni:  1.1e-8
Data Source:  BioPlex
SERPINC1
Tclin
Novelty:  0.00008721
p_int:  0.986092257
p_ni:  0.013901804
p_wrong:  0.000005939
Data Source:  BioPlex
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.980432138
p_ni:  0.019567862
Data Source:  BioPlex
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
p_int:  0.922501254
p_ni:  0.016301122
p_wrong:  0.061197625
Score:  0.542
Data Source:  BioPlex,STRINGDB
B4GALT5
Tbio
Family:  Enzyme
Novelty:  0.04538678
p_int:  0.909581952
p_ni:  0.068829534
p_wrong:  0.021588514
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.905471625
p_ni:  0.053059981
p_wrong:  0.041468394
Data Source:  BioPlex
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.88978948
p_ni:  0.11021052
Data Source:  BioPlex
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.884228497
p_ni:  0.115771503
Data Source:  BioPlex
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.871778116
p_ni:  0.128221884
Data Source:  BioPlex
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.853070456
p_ni:  0.146929544
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
3
3
97.3
IGF-1 measurement
1
2
2
90.3
central corneal thickness
1
1
0
2.4
64.4
risk-taking behaviour
1
1
1
59.6
BMI-adjusted waist-hip ratio
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
97.3
IGF-1 measurement
2
90.3
central corneal thickness
0
2.4
64.4
risk-taking behaviour
1
59.6
BMI-adjusted waist-hip ratio
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pro-melanin concentrating hormone
VGNC:5539
740957
Mouse
MGI:97629
110312
Rat
RGD:3358
24659
Dog
pro-melanin concentrating hormone
VGNC:44729
449022
Horse
pro-melanin concentrating hormone
VGNC:21610
100053268
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pro-melanin concentrating hormone
Mouse
Rat
Dog
pro-melanin concentrating hormone
Horse
pro-melanin concentrating hormone
Publication Statistics
PubMed Score 168.83
PubMed score by year
PubTator Score 948.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title