Tbio PMAIP1 Phorbol-12-myristate-13-acetate-induced protein 1

Protein Summary

Description

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Uniprot Accession IDs

• Q13794
• B2R4T7
• Q8N589
• PMA-induced protein 1

Gene Name

• PMAIP1

Ensembl ID

• ENST00000269518
• ENSP00000269518
• ENSG00000141682
• ENST00000316660
• ENSP00000326119

Symbol

• NOXA
• APR
• NOXA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
PubMedID	0.99
small molecule perturbation	0.99
virus perturbation	0.99
transcription factor perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.24   (req: < 5)

Gene RIFs: 110   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.24   (req: >= 5)

Gene RIFs: 110   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0